Results 41 to 50 of about 30,951 (226)
mBio, 2015 Stress granules (SGs) are dynamic cytoplasmic repositories containing translationally silenced mRNAs that assemble upon cellular stress. We recently reported that the SG nucleating protein G3BP1 promotes antiviral activity and is essential in double ...
Lucas C. Reineke +4 more
doaj +1 more source
Scientific Reports, 2021 Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR, plays a key role in the response to viral infections and cellular homeostasis by regulating mRNA translation.
Teresa Cesaro +5 more
doaj +1 more source
An antiviral response directed by PKR phosphorylation of the RNA helicase A. [PDF]
PLoS Pathogens, 2009 The double-stranded RNA-activated protein kinase R (PKR) is a key regulator of the innate immune response. Activation of PKR during viral infection culminates in phosphorylation of the alpha subunit of the eukaryotic translation initiation factor 2 ...
Anthony J Sadler +4 more
doaj +1 more source
eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
mBio, 2020 RNA-activated protein kinase (PKR) is a major innate immune factor that senses viral double-stranded RNA (dsRNA) and phosphorylates eukaryotic initiation factor (eIF) 2α. Phosphorylation of the α subunit converts the eIF2αβγ complex into a stoichiometric
Jennifer Deborah Wuerth +7 more
doaj +1 more source
TRIM21 restricts viral infection by inhibiting PKR signaling pathway activation.
, 2023 (A) Immunoblot analysis of IFNAR1 in wild-type A549 cells or HLCZ01 cells (sg-vector) or IFNAR1-deficient A549 or HLCZ01 cells (sg-IFNAR1). GAPDH was detected as an internal control.
Jingjing Wang (140791) +16 more
core +1 more source
PKR Activation Favors Infectious Pancreatic Necrosis Virus Replication in Infected Cells
Viruses, 2016 The double-stranded RNA-activated protein kinase R (PKR) is a Type I interferon (IFN) stimulated gene that has important biological and immunological functions.
Amr A.A. Gamil +3 more
doaj +1 more source
PKR Activation in Neurodegenerative Disease [PDF]
Journal of Neuropathology & Experimental Neurology, 2004 Interferon-inducible, double-stranded RNA-dependent protein kinase PKR is well known as an early cellular responder to viral infection. Activation of PKR has been associated with a number of downstream cell stress and cell death events, including a generalized shutdown of protein translation, activation of caspase-8, participation in JNK and p38 MAPK ...
openaire +2 more sources
Interaction of PKR with Single Stranded RNA [PDF]
Biophysical Journal, 2017 Abstract Although the antiviral kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulated by RNAs containing limited secondary structure. Single-stranded regions in such RNAs contribute to binding and activation but the mechanism is not understood.
Christopher B. Mayo, James L. Cole
openaire +3 more sources
Advanced Science, EarlyView.Controlled Pt–Pt fine structure in square‐planar Pt(II) complexes governs metal–metal‐to‐ligand charge‐transfer (MMLCT) state formation, exciton dynamics, and organic light‐emitting diode performance. Short Pt–Pt contacts in Pt(fppz)2 enable coherent metal–metal coupling, sub‐microsecond emission and an external quantum efficiency of 29%, whereas ...
Atul Shukla +15 more
wiley +1 more source