Results 61 to 70 of about 30,951 (226)

Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis

Journal of Virology
Protein kinase R (PKR) is an interferon-induced antiviral protein activated by autophosphorylation in response to double strand DNA (dsRNA) and other stimuli.
Daniel F. Edwards, III, Estela A. Pereira, Luiza A. Castro-Jorge, Juan M. Nevarez, Oded Foreman, Katherine R. Spindler   +5 more
doaj   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Functional domains and the antiviral effect of the double-stranded RNA-dependent protein kinase PKR from Paralichthys olivaceus

, 2008
The double-stranded RNA (dsRNA)-dependent protein kinase PKR is thought to mediate a conserved antiviral pathway by inhibiting viral protein synthesis via the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2 alpha).
Zhu, Rong, Zhang, Yi-Bing, Zhang, Qi-Ya, Gui, Jian-Fang, Gui, JF, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Grad Sch, Wuhan 430072, Peoples R China   +4 more
core   +1 more source

Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells. [PDF]

PLoS ONE, 2013
Dengue virus (DENV) is found in the tropical and subtropical regions and affects millions of people annually. Currently, no specific vaccine or antiviral treatment against dengue virus is available. Innate immunity has been shown to be important for host
Yuye Li, Jiong Xie, Siyu Wu, Jun Xia, Peifen Zhang, Chao Liu, Ping Zhang, Xi Huang   +7 more
doaj   +1 more source

Heparin Activates PKR by Inducing Dimerization [PDF]

Biophysical Journal, 2011
Protein kinase R (PKR) is an interferon-induced kinase that plays a pivotal role in the innate immunity pathway. PKR is activated to undergo autophosphorylation upon binding to double-stranded RNAs or RNAs that contain duplex regions. Activated PKR phosphorylates the α subunit of eukaryotic initiation factor 2, thereby inhibiting protein synthesis. PKR
Anderson, Eric, Pierre-Louis, Willythssa, Wong, C. Jason, Lary, Jeffrey W., Cole, James   +4 more
openaire   +3 more sources

A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition

Advanced Science, EarlyView.
These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li, Yuan Feng, Huazhi Chen, Jiamei Liu, Álvaro Fernández Montero, Jiangtao Gao, Jingqun Ao, Xinhua Chen   +7 more
wiley   +1 more source

Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy

Frontiers in Microbiology, 2021
Tuberculosis (TB) is a deadly infectious lung disease caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb). The identification of macrophage signaling proteins exploited by Mtb during infection will enable the development of alternative ...
Robin Smyth, Stefania Berton, Nusrah Rajabalee, Therese Chan, Jim Sun, Jim Sun   +5 more
doaj   +1 more source

Biochemical Analysis of PKR Activation by PACT [PDF]

Biochemistry, 2009
Many extracellular stresses cause inhibition of translation initiation by triggering phosphorylation of the initiation factor, eIF-2alpha. A major protein kinase responsible for this phosphorylation is PKR, a latent kinase which itself needs to be activated by autophosphorylation.
Gregory A, Peters, Benjamin, Dickerman, Ganes C, Sen   +2 more
openaire   +2 more sources

CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER‐phagy and Suppress Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru, Lunbiao Gan, Yu Lu, Yujing Guo, Qian Huang, Sha Yin, Fengze Nie, Sijia Di, Jiaqi Ning, Siyu Yao, Huanhuan Wan, Le Liu, Zehua Liu, Fa Yang, Weijun Qin, Weihong Wen   +15 more
wiley   +1 more source

Protein kinase R regulates pancreatic ductal adenocarcinoma progression by modulating the cell cycle via GADD45A

Scientific Reports
Protein kinase R (PKR) functions both as a promoter and inhibitor in various cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We investigated the role of PKR in PDAC.
Yuki Numata, Mitsuhito Koizumi, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Kaori Marui, Sho Ishikawa, Masahito Kokubu, Yusuke Okujima, Yoshiki Imamura, Teruki Miyake, Teru Kumagi, Yoichi Hiasa   +12 more
doaj   +1 more source