Duck Hepatitis A Virus Type 1 Induces eIF2α Phosphorylation-Dependent Cellular Translation Shutoff via PERK/GCN2 [PDF]
Frontiers in Microbiology, 2021 Duck hepatitis A virus type 1 (DHAV-1) is one of the most deadly pathogens that endanger the duck industry. Most viruses usually turn off host translation after infection to facilitate viral replication and translation.
Yuanzhi Liu +56 more
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Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice [PDF]
Cellular & Molecular Biology Letters, 2023 Background Lupus nephritis (LN) is associated with significant mortality and morbidity, while effective therapeutics and biomarkers are limited since the pathogenesis is complex. This study investigated the roles of the CEBPB/BZW1/eIF2α axis in metabolic
Huimeng Qi, Zhaoguo Zheng, Qiang Liu
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eIF2α phosphorylation-ATF4 axis-mediated transcriptional reprogramming mitigates mitochondrial impairment during ER stress [PDF]
Molecules and Cells: Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, which regulates all 3 unfolded protein response pathways, helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional and translational ...
Hien Thi Le +13 more
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Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication [PDF]
Frontiers in Veterinary Science, 2021 Peste des petits ruminant virus (PPRV) causes a highly contagious disease in small ruminants. The molecular mechanism of PPRV replication and its interactions with hosts are poorly studied.
Niyokwishimira Alfred +9 more
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EIF2α phosphorylation: a hallmark of both autophagy and immunogenic cell death [PDF]
Molecular & Cellular Oncology, 2020 Different intrinsic and extrinsic stress pathways including endoplasmic reticulum (ER) stress converge on the phosphorylation of eukaryotic translation initiation factor 2A (EIF2A, best known as eIF2α), which characterizes the so-called “integrated ...
Juliette Humeau +3 more
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Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells [PDF]
Cell ReportsSummary: The integrated stress response (ISR) is critical for cell survival under stress. In response to diverse environmental cues, eIF2α becomes phosphorylated, engendering a dramatic change in mRNA translation.
Mehdi Amiri +16 more
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eIF2α phosphorylation: A hallmark of immunogenic cell death [PDF]
OncoImmunology, 2018 Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely
Lucillia Bezu +5 more
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Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections [PDF]
Frontiers in Immunology, 2019 The guanabenz derivative Sephin1 has recently been proposed to increase the levels of translation initiation factor 2 (eIF2α) phosphorylation by inhibiting dephosphorylation by the protein phosphatase 1—GADD34 (PPP1R15A) complex.
Maxime Fusade-Boyer +16 more
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Journal of Marine Science and Engineering, 2022 The present study investigates the response of the marine fish cobia, Rachycentron canadum, to stressors as measured by phosphorylation of the α-subunit of the translational initiation factor, eIF2.
Chieh Lun Liu +4 more
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Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment. [PDF]
PLoS ONE, 2013 In an effort to circumvent resistance to rapamycin--an mTOR inhibitor--we searched for novel rapamycin-downstream-targets that may be key players in the response of cancer cells to therapy.
Liron Tuval-Kochen +9 more
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