Results 21 to 30 of about 363,972 (179)
Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway. [PDF]
, 2017 Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2 which encodes polycystin-1 (PC1) and polycystin-2, respectively.
Jingfeng Tang +8 more
core +2 more sources
eIF2α Phosphorylation Mediates IL24-Induced Apoptosis through Inhibition of Translation. [PDF]
Mol Cancer Res, 2017 IL24 is an immunomodulatory cytokine that also displays broad cancer-specific suppressor effects. The tumor-suppressor activities of IL24 include inhibition of angiogenesis, sensitization to chemotherapy, and cancer-specific apoptosis.
Persaud L +7 more
europepmc +2 more sources
Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons
, 2023 Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress–induced unfolded protein response (UPR).
Kwang Kon Kim (511710) +13 more
core +1 more source
The role of host eIF2α in viral infection
Virology Journal, 2020 Background eIF2α is a regulatory node that controls protein synthesis initiation by its phosphorylation or dephosphorylation. General control nonderepressible-2 (GCN2), protein kinase R-like endoplasmic reticulum kinase (PERK), double-stranded RNA (dsRNA)
Yuanzhi Liu +26 more
doaj +1 more source
CHANGES IN eIF2α PHOSPHORYLATION IN RESPONSE TO NUTRIENT DEFICIENCY AND OTHER STRESSORS IN FISH [PDF]
, 2015 The present study investigates the response of two teleost species to stressors as measured by phosphorylation of the α-subunit of the translational initiation factor, eIF2.
Liu, Chieh-lun
core +1 more source
Cell Reports, 2017 Tumor necrosis factor alpha (TNF-α) is expressed promptly during inflammatory responses. Efficient TNF-α mRNA splicing is achieved through a 3′ UTR element that activates RNA-dependent eIF2α protein kinase (PKR).
Lise Sarah Namer +5 more
doaj +1 more source
eLife, 2015 Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013).
Carmela Sidrauski +3 more
doaj +1 more source
eIF2α kinases regulate development through the BzpR transcription factor in Dictyostelium discoideum. [PDF]
PLoS ONE, 2012 A major mechanism of translational regulation in response to a variety of stresses is mediated by phosphorylation of eIF2α to reduce delivery of initiator tRNAs to scanning ribosomes.
Charles K Singleton +3 more
doaj +1 more source
Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons
, 2023 Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR).
Dasol Kang +27 more
core +1 more source
BMC Cell Biology, 2009 Background The ErbB2/Her2/Neu receptor tyrosine kinase is amplified in ~30% of human breast cancers. Phosphorylation of the translation initiation factor, eIF2α inhibits global protein synthesis and activates a stress signaling and growth suppressive ...
Avivar-Valderas Alvaro +4 more
doaj +1 more source