GADD34 Activates p53 and May Have Utility as a Marker of Atherosclerosis
Frontiers in Medicine, 2023 We previously identified growth arrest and DNA-damage-inducible gene 34 (GADD34) as a marker of ischemic stroke. In the present study, serum levels of anti-GADD34 antibodies were found to be significantly higher in patients with acute ischemic stroke or ...
Takaki Hiwasa +2 more
exaly +3 more sources
Cell Reports, 2017 Summary: GADD34, a stress-induced regulatory subunit of the phosphatase PP1, is known to function in hyperosmotic stress through its well-known role in the integrated stress response (ISR) pathway.
Dawid Krokowski +2 more
exaly +3 more sources
TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites. [PDF]
Nat CommunInter-organelle contact sites are key hubs for organelle bidirectional crosstalk. However, how mitochondria and RNA granules interact at contact sites and its regulation by mitochondrial oxidative phosphorylation (OXPHOS) remain unclear.
Ball HE, Woods AC, Wong YC.
europepmc +2 more sources
SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress. [PDF]
Nat CommunRNA splicing is fundamental to cellular function, yet systematic investigation of its complex regulation has been limited by existing methods. Here, we present SPLiCR-seq (SPLicing regulator identification through CRISPR screening), a high-throughput ...
Ying Q, Chen Y, Shen L, Xu Y, Tian R.
europepmc +2 more sources
Roles of the integrated stress response in regulation of inflammatory reactions. [PDF]
Front ImmunolThe integrated stress response (ISR) is a conserved cyto-protective mechanism, which has fundamental roles in maintaining cell viability under various conditions when intracellular and/or extracellular homeostasis is disrupted.
Jiang F, Liu GS, Liu J, Cui X, Xing Y.
europepmc +2 more sources
Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung-Derived Cell Lines. [PDF]
VirusesThe betacoronavirus genus contains five of the seven human coronaviruses, making it a particularly critical area of research to prepare for future viral emergence. We utilized three human betacoronaviruses, one from each subgenus—HCoV-OC43 (embecovirus),
Renner DM +3 more
europepmc +2 more sources
Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation
Microbiology Spectrum, 2022 Enterovirus 71 (EV71) is the major pathogen of hand, foot, and mouth disease. In severe cases, it can cause life-threatening neurological complications, such as aseptic meningitis and polio-like paralysis.
Hui Li +7 more
doaj +1 more source
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal
Life Science Alliance, 2022 ATRA increases GADD34 expression by decreasing the expression of Six1, which down-regulates the transcriptional activity with TLE3 and increasing mRNA stability through blocking the interaction between TTP and ARE on GADD34 mRNA, resulting in muscle ...
Yuichiro Adachi +12 more
doaj +1 more source
GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy. [PDF]
PLoS ONE, 2016 The balance of protein synthesis and proteolysis (i.e. proteostasis) is maintained by a complex regulatory network in which mTOR (mechanistic target of rapamycin serine/threonine kinase) pathway and unfolded protein response are prominent positive and ...
Marianna Holczer +2 more
doaj +1 more source
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection. [PDF]
PLoS Pathogens, 2012 Nucleic acid sensing by cells is a key feature of antiviral responses, which generally result in type-I Interferon production and tissue protection.
Giovanna Clavarino +10 more
doaj +1 more source