Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase [PDF]
Cell Reports, 2015 The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress response of all eukaryotic cells. The growth-arrest- and DNA-damage-induced transcript 34 (GADD34) bound to the serine/threonine protein phosphatase 1 (PP1) is the ...
Meng S. Choy +7 more
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EBNA3C interacts with Gadd34 and counteracts the unfolded protein response [PDF]
Virology Journal, 2009 EBNA3C is an EBV-encoded nuclear protein, essential for proliferation of EBV infected B-lymphocytes. Using EBNA3C amino acids 365-545 in a yeast two hybrid screen, we found an interaction with the Growth Arrest and DNA-damage protein, Gadd34.
Takada Kenzo +3 more
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Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS
Neurobiology of Disease, 2020 Mutations in Cu/Zn superoxide dismutase (SOD1) cause ~20% of familial ALS (FALS), which comprises 10% of total ALS cases. In mutant SOD1- (mtSOD1-) induced ALS, misfolded aggregates of SOD1 lead to activation of the unfolded protein response/integrated ...
Ghanashyam D. Ghadge +6 more
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Molecular docking studies of salubrinal and its analogs as inhibitors of the GADD34:PP1 enzyme [PDF]
ADMET and DMPK, 2019 The phenomenon of the endoplasmic reticulum (ER) stress as a molecular pathophysiological process underlies diseases as cancer, diabetes mellitus, myocardial infarction, neurodegenerative disorders, diseases of the urinary system, disorders associated ...
Pavlo V. Zadorozhnii +4 more
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Proteostasis in the regulation of pancreatic islet cell plasticity. [PDF]
J Diabetes InvestigAdaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Shirakawa J.
europepmc +2 more sources
Melatonin Regulates Growth-Arrest and DNA-Damage Genes GADD153, GADD45g and GADD34 in Experimental Varicocele. [PDF]
Cell Biochem FunctABSTRACT This study aimed to reveal the relationship between experimental varicocele and melatonin levels. Forty adult Wistar albino rats were used in this study. Control (C), Melatonin (M), Varicocele (V), Varicocele+Melatonin (V + M) were planned. Varicocele was created on the first day of the experiment by opening the abdominal area, narrowing the ...
Önal E, Baydilli N, Karabulut D.
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Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer. [PDF]
Adv Sci (Weinh)RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lyu L +13 more
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GADD34 is a modulator of autophagy during starvation [PDF]
Science Advances, 2020 In response to starvation, cells tune protein synthesis to promote autophagy, thus ensuring nutrient recycling and survival.
Gambardella, Gennaro +12 more
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Capsaicin Modulates DNA Damage Related Gene Expressions in Cisplatin-Induced Ototoxicity. [PDF]
Laryngoscope Investig OtolaryngolABSTRACT Objectives Cisplatin (CDDP) is a potent anticancer agent with significant side effects, including ototoxicity. Capsaicin (CAPS), the active compound in chili peppers, has shown protective effects against CDDP‐induced toxicities. This study aimed to investigate the role of capsaicin in CDDP‐induced ototoxicity via DNA damage and apoptotic cell ...
Altun YK +4 more
europepmc +2 more sources
Human BAG-1 Proteins Bind to the Cellular Stress Response Protein GADD34 and Interfere with GADD34 Functions [PDF]
Molecular and Cellular Biology, 2003 The cellular stress response protein GADD34 mediates growth arrest and apoptosis in response to DNA damage, negative growth signals, and protein malfolding. GADD34 binds to protein phosphatase PP1 and can attenuate the translational elongation of key transcriptional factors through dephosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha ...
Wesley J, Hung +3 more
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