Results 31 to 40 of about 4,821 (166)

GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice

International Journal of Molecular Sciences, 2022
The UPR is sustainably activated in degenerating retinas, leading to translational inhibition via p-eIF2α. Recent findings have demonstrated that ablation of growth arrest and DNA damage-inducible protein 34 (GADD34), a protein phosphatase 1 regulatory subunit permitting translational machinery operation through p-eIF2α elevation, does not impact the ...
Irina V. Saltykova, Assylbek Zhylkibayev, Oleg S. Gorbatyuk, Marina S. Gorbatyuk   +3 more
openaire   +2 more sources

Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation

Cellular Physiology and Biochemistry, 2018
Background/Aims: Tonsillectomy may be an important method to achieve a long-term remission of IgAN, but patients’ physical status may limit their access to this surgery. We proposed an encouraging solution through inhibiting GADD34 expression in order to
Xiaofei Peng, Tao Yang, Liyu He, Xian Chen, Yafeng Jiang, Hao Zhang, Hong Liu, Youming Peng   +7 more
doaj   +1 more source

Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis

Cell Death and Disease, 2022
The purpose of the current study was to define the role of MAX interactor 1 (Mxi1) in the pathogenesis of lung cancer and its underlying molecular mechanism.
Yujie Lei, Yunchao Huang, Jianbin Lin, Shihui Sun, Keda Che, Junting Shen, Jun Liao, Yangming Chen, Kai Chen, Zhaoxian Lin, Xing Lin   +10 more
doaj   +1 more source

Induction of GADD34 Regulates the Neurotoxicity of Amyloid β

American Journal of Alzheimer's Disease & Other Dementias®, 2014
The possible roles played by growth arrest and DNA damage-inducible gene 34 (GADD34) in Alzheimer’s disease (AD) are so far less understood. In this study, we found that GADD34 was increased in the brains of AD transgenic J20 mice. The deposition of β-amyloid (Aβ) peptide is the main component of neurotic plaques in AD brain.
Niangui, Xu, Zhijie, Xiao, Ting, Zou, Zhiling, Huang   +3 more
openaire   +2 more sources

Association with Endoplasmic Reticulum Promotes Proteasomal Degradation of GADD34 Protein [PDF]

Journal of Biological Chemistry, 2011
Stress-induced endogenous and ectopically expressed GADD34 proteins were present both in the cytoplasm and in membranes, with their membrane association showing similar biochemical properties. Deletion of N-terminal sequences in GADD34-GFP proteins highlighted an amphipathic helix, whose hydrophobic surface, specifically valine 25 and leucine 29 ...
Zhou, W., Brush, M.H., Choy, M.S., Shenolikar, S.   +3 more
openaire   +2 more sources

GADD34 induces p21 expression and cellular senescence

Oncology Reports, 2007
We previously identified GADD34 (growth arrest and DNA damage protein 34) by screening for genes involved in oncogenic-transformation and/or cellular senescence in Ras-transformed rat F2408 fibroblasts (7EJ-Ras), which exhibit anchorage-independent growth and do not senesce.
Kahori, Minami, Hirokazu, Inoue, Takao, Terashita, Takahiro, Kawakami, Ryosuke, Watanabe, Masataka, Haneda, Ken-Ichi, Isobe, Hidetoshi, Okabe, Tokuhiro, Chano   +8 more
openaire   +3 more sources

Design, Development and Optimization of a Functional Mammalian Cell-Free Protein Synthesis Platform

Frontiers in Bioengineering and Biotechnology, 2021
In this paper, we describe the stepwise development of a cell-free protein synthesis (CFPS) platform derived from cultured Chinese hamster ovary (CHO) cells.
Chiara Heide, Chiara Heide, Chiara Heide, Gizem Buldum, Ignacio Moya-Ramirez, Ignacio Moya-Ramirez, Oscar Ces, Oscar Ces, Cleo Kontoravdi, Karen M. Polizzi, Karen M. Polizzi   +10 more
doaj   +1 more source

Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in rats

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To investigate the influence of edaravone on the expression of growth arrest and DNA damage-inducible protein 34 (GADD34). Methods: A total of 108 healthy male Sprague-Dawley rats were randomly divided into sham operation group, model group ...
Wei Wang, Xiao-Mei Wu, Bo Jiang, Chun-Yu Wang, Hai-Nan Zhang, Xiang-Min Shen   +5 more
doaj   +1 more source

Characterization of circSEC11A as a novel regulator of Iodine-125 radioactive seed-induced anticancer effects in hepatocellular carcinoma via targeting ZHX2/GADD34 axis

Cell Death Discovery, 2023
Iodine-125 (I-125) radioactive seed implantation is used for the local treatment of hepatocellular carcinoma (HCC), but the molecular mechanisms regulating its anticancer effects remain incompletely understood.
Dong Li, Wujie Wang, Bin Liu, Die Jin, Yang Wang, Guanghui He, Lei Guo, Wen Liu, Yuliang Li   +8 more
doaj   +1 more source

Inhibition of GADD34, the stress-inducible regulatory subunit of the endoplasmic reticulum stress response, does not enhance functional recovery after spinal cord injury.

PLoS ONE, 2014
Activation of the endoplasmic reticulum stress response (ERSR) is a hallmark of various pathological diseases and/or traumatic injuries. Restoration of ER homeostasis can contribute to improvement in the functional outcome of these diseases.
Sujata Saraswat Ohri, Ashley Mullins, Michal Hetman, Scott R Whittemore   +3 more
doaj   +1 more source