Results 51 to 60 of about 4,821 (166)

Inhibition of IRE1 modifies the hypoxic regulation of GADD family gene expressions in U87 glioma cells [PDF]

The Ukrainian Biochemical Journal, 2016
We have studied hypoxic regulation of the expression of genes encoded GADD (growth arrest and DNA damage) family proteins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1), which controls cell proliferation and tumor ...
O. H. Minchenko, I. V. Kryvdiuk, О. O. Riabovol, D. O. Minchenko, S. V. Danilovskyi, О. O. Ratushna   +5 more
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Modulation of Endoplasmic Reticulum Stress via CEBPB: A Potential Molecular Link to Therapeutic Action in Substance Use Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
We identified endoplasmic reticulum (ER) stress modulation as a convergent transcription signature across fentanyl and multiple substance use disorder (SUD)‐relevant treatments. Key ER stress genes, including TRIB3, XBP1, and DDIT3, were downregulated, while CEBPB emerged as a shared upstream regulator linked to ER stress–related proteins.
Cheng Zhang, Hu Li, Ming‐Fen Ho
wiley   +1 more source

CHOP upregulation and dysregulation of the mature form of the SNAT2 amino acid transporter in the placentas from small for gestational age newborns

Cell Communication and Signaling, 2023
Background The placentas from newborns that are small for gestational age (SGA; birth weight 
Emma Barroso, Marta Díaz, Ana Cristina Reguera, Mona Peyman, Jesús Balsinde, Javier Jurado-Aguilar, Meijian Zhang, Adel Rostami, Xavier Palomer, Lourdes Ibáñez, Manuel Vázquez-Carrera   +10 more
doaj   +1 more source

Recalibrating the apoptotic threshold: Ubiquitin‐regulated ER stress signalling in colorectal cancer

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Ubiquitin‐dependent turnover of ER‐stress sensors, proteostasis factors, and apoptotic regulators can recalibrate the apoptotic threshold in colorectal cancer, balancing adaptive survival against terminal cell death. Defining these context‐dependent vulnerabilities may enable strategies that overcome stress adaptation and restore apoptotic competence ...
Jing Hu, Shanliang Zheng, Ying Hu
wiley   +1 more source

The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation

Cell Reports
Summary: Neuronal protein synthesis is required for long-lasting plasticity and long-term memory consolidation. Dephosphorylation of eukaryotic initiation factor 2α is one of the key translational control events that is required to increase de novo ...
Mauricio M. Oliveira, Muhaned Mohamed, Megan K. Elder, Keylin Banegas-Morales, Maggie Mamcarz, Emily H. Lu, Ela A.N. Golhan, Nishika Navrange, Snehajyoti Chatterjee, Ted Abel, Eric Klann   +10 more
doaj   +1 more source

Serum From Preeclamptic Women Triggers Endoplasmic Reticulum Stress Pathway and Expression of Angiogenic Factors in Trophoblast Cells

Frontiers in Physiology, 2022
Preeclampsia (PE) is a hypertensive disease of pregnancy-associated with placental cell death and endoplasmic reticulum (ER) stress. It is unknown whether systemic factors aggravate placental dysfunction. We investigated whether serum factors in pregnant
Karla R. Castro, Karen M. Prado, Aline R. Lorenzon, Aline R. Lorenzon, Mara S. Hoshida, Eliane A. Alves, Rossana P. V. Francisco, Marcelo Zugaib, Aldilane L. X. Marques, Elaine C. O. Silva, Eduardo J. S. Fonseca, Alexandre U. Borbely, Mariana M. Veras, Estela Bevilacqua   +13 more
doaj   +1 more source

ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Nature Communications, 2020
Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus
Ramesh B. Kasetti, Pinkal D. Patel, Prabhavathi Maddineni, Shruti Patil, Charles Kiehlbauch, J. Cameron Millar, Charles C. Searby, VijayKrishna Raghunathan, Val C. Sheffield, Gulab S. Zode   +9 more
doaj   +1 more source

Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer’s disease mouse model: a role for ER-mitochondria interaction

Cell Death and Disease, 2022
Deregulation of protein synthesis and ER stress/unfolded protein response (ER stress/UPR) have been reported in astrocytes. However, the relationships between protein synthesis deregulation and ER stress/UPR, as well as their role in the altered ...
Laura Tapella, Giulia Dematteis, Marianna Moro, Beatrice Pistolato, Elisa Tonelli, Virginia Vita Vanella, Daniele Giustina, Aleida La Forgia, Elena Restelli, Elettra Barberis, Tito Cali, Marisa Brini, Salvatore Villani, Erika Del Grosso, Mariagrazia Grilli, Marcello Manfredi, Marco Corazzari, Ambra A. Grolla, Armando A. Genazzani, Dmitry Lim   +19 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, Volume 16, Issue 9, Page 1766-1785, September 2026.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source