Results 41 to 50 of about 4,821 (166)

The crosstalk between MYC and mTORC1 during osteoclastogenesis

Frontiers in Cell and Developmental Biology, 2022
Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption.
Seyeon Bae, Seyeon Bae, Brian Oh, Jefferson Tsai, Peter Sang Uk Park, Matthew Blake Greenblatt, Eugenia G. Giannopoulou, Eugenia G. Giannopoulou, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min   +10 more
doaj   +1 more source

The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP)

International Journal of Molecular Sciences, 2023
The vertebrate PPP1R15 family consists of the proteins GADD34 (growth arrest and DNA damage-inducible protein 34, the product of the PPP1R15A gene) and CReP (constitutive repressor of eIF2α phosphorylation, the product of the PPP1R15B gene), both of which function as targeting/regulatory subunits for protein phosphatase 1 (PP1) by regulating ...
Danielle Hicks, Krithika Giresh, Lisa A. Wrischnik, Douglas C. Weiser   +3 more
openaire   +2 more sources

Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats

Cell Reports, 2018
Summary: Reduced eukaryotic Initiation Factor 2 (eIF2)α phosphorylation (p-eIF2α) enhances protein synthesis, memory formation, and addiction-like behaviors.
Philippe A. Melas, Johanna S. Qvist, Matteo Deidda, Chirag Upreti, Ya Bin Wei, Fabrizio Sanna, Walter Fratta, Maria Scherma, Paola Fadda, Denise B. Kandel, Eric R. Kandel   +10 more
doaj   +1 more source

Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing [PDF]

BioMed Research International, 2014
The growth arrest and DNA damage-inducible protein, GADD34, has been proved to be involved in TGF-βsignaling pathway and correlates with cell death, which are two important mechanisms in regulating myofibroblast differentiation and apoptosis during tissue repair. But roles of GADD34 in myofibroblasts differentiation and apoptosis remain unknown.
Liu, Lintao, Nishio, Naomi, Ito, Sachiko, Tanaka, Yuriko, Isobe, Ken-ichi   +4 more
openaire   +2 more sources

Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.

PLoS Pathogens, 2015
Pseudomonas aeruginosa infection can be disastrous in chronic lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease. Its toxic effects are largely mediated by secreted virulence factors including pyocyanin, elastase and alkaline
Emily F A van 't Wout, Annemarie van Schadewijk, Ria van Boxtel, Lucy E Dalton, Hanna J Clarke, Jan Tommassen, Stefan J Marciniak, Pieter S Hiemstra   +7 more
doaj   +1 more source

GADD34 Promotes Tumor Growth by Inducing Myeloid-derived Suppressor Cells [PDF]

Anticancer Research, 2016
Tumor hypoxia induces the expression of growth arrest and DNA damage-inducible protein (GADD34). However, the role of GADD34 in tumor growth remains unclear.Gadd34 expression was knocked-down through lentivirus-mediated short hairpin RNA (shRNA) in tumor cells, which were subsequently injected subcutaneously into mice. Tumor volumes and myeloid-derived
Lintao, Liu, Sachiko, Ito, Naomi, Nishio, Yang, Sun, Yuriko, Tanaka, Ken-Ichi, Isobe   +5 more
openaire   +2 more sources

A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells. [PDF]

PLoS ONE, 2008
Mutations in eukaryotic translation initiation factor 2B (eIF2B) cause Childhood Ataxia with CNS Hypomyelination (CACH), also known as Vanishing White Matter disease (VWM). The disease is manifested by loss of brain myelin upon physiological stress. In a
Liraz Kantor, Dalia Pinchasi, Michelle Mintz, Yetrib Hathout, Adeline Vanderver, Orna Elroy-Stein   +5 more
doaj   +1 more source

Schwann Cell‐Specific ATG7‐Dependent Autophagy Protects Myelin in a Mouse Model of Krabbe Disease

Glia, Volume 74, Issue 12, December 2026.
Krabbe disease (KD) is caused by mutations in GALC and deregulated lysosomal function in Schwann cells (SCs). Using a SC‐specific Galc‐cKO mouse, we identified altered autophagy in SCs during KD progression. Further ablation of Atg7 in SCs of KD worsened disease severity.
Narayan Dhimal, Aditya Sidharth, Jiajun Zhang, Trina Rudra, Edward Hurley, Pablo M. Paez, Fraser J. Sim, Daesung Shin, M. Laura Feltri   +8 more
wiley   +1 more source

GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor [PDF]

The Journal of Cell Biology, 2004
The cascade of phosphorylation is a pivotal event in transforming growth factor β (TGFβ) signaling. Reversible phosphorylation regulates fundamental aspects of cell activity. TGFβ-induced Smad7 binds to type I receptor (TGFβ type I receptor; TβRI) functioning as a receptor kinase antagonist.
Shi, Weibin, Sun, Chuanxi, He, Bin, Xiong, Wencheng, Shi, Xingming, Yao, Dachun, Cao, Xu   +6 more
openaire   +2 more sources

SARS-CoV-2 Nucleocapsid Protein Antagonizes GADD34-Mediated Innate Immune Pathway through Atypical Foci

Molecules
The integrated stress response, especially stress granules (SGs), contributes to host immunity. Typical G3BP1+ stress granules (tSGs) are usually formed after virus infection to restrain viral replication and stimulate innate immunity.
Jie Liu, Guanwen Guan, Chunxiu Wu, Bingbing Wang, Kaifei Chu, Xu Zhang, Su He, Naru Zhang, Geng Yang, Zhigang Jin, Tiejun Zhao   +10 more
doaj   +1 more source