Results 21 to 30 of about 4,821 (166)

Gadd34 Requirement for Normal Hemoglobin Synthesis [PDF]

Molecular and Cellular Biology, 2006
The protein encoded by growth arrest and DNA damage-inducible transcript 34 (Gadd34) is associated with translation initiation regulation following certain stress responses. Through interaction with the protein phosphatase 1 catalytic subunit (PP1c), Gadd34 recruits PP1c for the removal of an inhibitory phosphate group on the alpha subunit of ...
Andrew D, Patterson, M Christine, Hollander, Georgina F, Miller, Albert J, Fornace   +3 more
openaire   +2 more sources

Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins [PDF]

Molecular and Cellular Biology, 1999
One of the most common chromosomal abnormalities in acute leukemia is a reciprocal translocation involving the HRX gene (also called MLL, ALL-1, or HTRX) at chromosomal locus 11q23, resulting in the formation of HRX fusion proteins. Using the yeast two-hybrid system and human cell culture coimmunoprecipitation experiments, we show here that HRX ...
H T, Adler, R, Chinery, D Y, Wu, S J, Kussick, J M, Payne, A J, Fornace, D C, Tkachuk   +6 more
openaire   +2 more sources

Control of Cellular GADD34 Levels by the 26S Proteasome [PDF]

Molecular and Cellular Biology, 2008
GADD34, the product of a growth arrest and DNA damage-inducible gene, is expressed at low levels in unstressed cells. In response to stress, the cellular content of GADD34 protein increases and, on termination of stress, rapidly declines. We investigated the mechanisms that control GADD34 levels in human cells.
Brush, M.H., Shenolikar, S.
openaire   +2 more sources

Prototypic P2X7 Receptor Agonist, BzATP, Induced the Expression of Unfolded Protein Response Genes in Human M1 Macrophages

Iranian Journal of Allergy, Asthma and Immunology, 2022
Purinergic receptors stimulation by adenosine triphosphate (ATP) contributes significantly to macrophage activation, and also macrophage cell death.
Maryam Akhtari, Seyed Jalal Zargar, Ali Javinani, Amir Ashraf-Ganjouei, Mahdi Vojdanian, Ahmadreza Jamshidi, Mahdi Mahmoudi   +6 more
doaj   +1 more source

Mammalian GADD34, an Apoptosis- and DNA Damage-inducible Gene [PDF]

Journal of Biological Chemistry, 1997
The mammalian cellular response to genotoxic stress is a complex process involving many known and probably many as yet unknown genes. Induction of the human DNA damage- and growth arrest-inducible gene, GADD34, by ionizing radiation was only seen in certain cell lines and correlated with apoptosis following ionizing radiation. In addition, the kinetics
M C, Hollander, Q, Zhan, I, Bae, A J, Fornace   +3 more
openaire   +2 more sources

Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation

Frontiers in Cell and Developmental Biology, 2023
Adequate lung epithelial repair relies on supportive interactions within the epithelial niche, including interactions with WNT-responsive fibroblasts.
P. P. S. J. Khedoe, W. A. A. M. van Schadewijk, M. Schwiening, J. P. Ng-Blichfeldt, J. P. Ng-Blichfeldt, S. J. Marciniak, J. Stolk, R. Gosens, P. S. Hiemstra   +8 more
doaj   +1 more source

Disruption of the PP1/GADD34 complex induces calreticulin exposure [PDF]

Cell Cycle, 2009
In response to some chemotherapeutic agents, tumor cells can translocate calreticulin (CRT), which is usually contained in the lumen of the endoplasmic reticulum, to the surface of the plasma membrane. This effect requires the phosphorylation of the eukaryotic initiation factor 2alpha(eIF2alpha) by the eIF2alpha kinase PERK, yet may also be triggered ...
Oliver, Kepp, Lorenzo, Galluzzi, Fabrizio, Giordanetto, Antoine, Tesniere, Ilio, Vitale, Isabelle, Martins, Frederic, Schlemmer, Sandy, Adjemian, Laurence, Zitvogel, Guido, Kroemer   +9 more
openaire   +2 more sources

GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis

Veterinary Research, 2021
Viruses have evolved multiple strategies to manipulate their host’s translational machinery for the synthesis of viral proteins. A common viral target is the alpha subunit of eukaryotic initiation factor 2 (eIF2α).
Ting Zhu, Xueli Jiang, Hangkuo Xin, Xiaohui Zheng, Xiaonuan Xue, Ji-Long Chen, Baomin Qi   +6 more
doaj   +1 more source

A systems biological analysis of the ATF4‐GADD34‐CHOP regulatory triangle upon endoplasmic reticulum stress

FEBS Open Bio, 2022
Endoplasmic reticulum (ER) stress‐dependent accumulation of incorrectly folded proteins leads to activation of the unfolded protein response. The role of the unfolded protein response (UPR) is to avoid cell damage and restore the homeostatic state by ...
Margita Márton, Gábor Bánhegyi, Norbert Gyöngyösi, Eszter Éva Kálmán, Aladár Pettkó‐Szandtner, Krisztina Káldi, Orsolya Kapuy   +6 more
doaj   +1 more source

Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction

Frontiers in Cellular Neuroscience, 2022
Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery that might lead to a decline in learning and memory. Oxidative stress damage is one of the pathogenic mechanisms underlying POCD.
Linhao Jiang, Linhao Jiang, Linhao Jiang, Linhao Jiang, Rui Dong, Rui Dong, Rui Dong, Rui Dong, Minhui Xu, Minhui Xu, Minhui Xu, Yujia Liu, Yujia Liu, Yujia Liu, Yujia Liu, Jiyan Xu, Jiyan Xu, Jiyan Xu, Jiyan Xu, Zhengliang Ma, Tianjiao Xia, Tianjiao Xia, Tianjiao Xia, Xiaoping Gu   +23 more
doaj   +1 more source