Results 61 to 70 of about 4,821 (166)

GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy [PDF]

Scientific Reports, 2015
AbstractAutophagy is a common physiological function in all eukaryotes. The process is induced by depletion of nutrients including amino acids. GADD34 is expressed following DNA damage, ER stresses and amino acid deprivation. Here, we investigated the effects of GADD34 on autophagy and cell activation in macrophages.
Sachiko Ito, Yuriko Tanaka, Reina Oshino, Keiko Aiba, Suganya Thanasegaran, Naomi Nishio, Ken-ichi Isobe   +6 more
openaire   +2 more sources

Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease? [PDF]

PLoS ONE, 2011
BACKGROUND: Endoplasmic reticulum (ER) stress has been suggested to play a role in inflammatory bowel disease (IBD). The three branches (ATF6, IRE1 and PERK) of the unfolded protein response (UPR) have different roles and are not necessarily activated ...
Sara Bogaert, Martine De Vos, Kim Olievier, Harald Peeters, Dirk Elewaut, Bart Lambrecht, Philippe Pouliot, Debby Laukens   +7 more
doaj   +1 more source

Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication

Frontiers in Veterinary Science, 2021
Peste des petits ruminant virus (PPRV) causes a highly contagious disease in small ruminants. The molecular mechanism of PPRV replication and its interactions with hosts are poorly studied.
Niyokwishimira Alfred, Niyokwishimira Alfred, Bang Qian, Xiaodong Qin, Xiangping Yin, Meera Prajapati, Meera Prajapati, Yongxi Dou, Yanmin Li, Zhidong Zhang   +9 more
doaj   +1 more source

The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS

Neurobiology of Disease, 2019
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord.
Yulia Dzhashiashvili, Chase P. Monckton, Harini S. Shah, Rejani B. Kunjamma, Brian Popko   +4 more
doaj   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

GADD34 Gene Restores Virulence in Viral Vector Used in Experimental Stroke Study [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2007
GADD34 is expressed in the ischaemic brain and reverses protein synthesis shutdown. Consequently, GADD34 could have neuroprotective potential in stroke. BHK medium, a replication-deficient HSV viral vector (HSV1716) with no insert or containing full-length GADD34, the N terminal or a conserved portion of the gene, was injected into
McCabe, C., White, F., Brown, S.M., Macrae, I.M.   +3 more
openaire   +3 more sources

Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis

Neurobiology of Disease, 2014
Approximately 20% of familial amyotrophic lateral sclerosis (FALS) cases are caused by mutant superoxide dismutase type 1 (mtSOD1). Although the mechanisms of mtSOD1-induced toxicity remain poorly understood, evidence suggests that accumulation of ...
Lijun Wang, Brian Popko, Emily Tixier, Raymond P. Roos   +3 more
doaj   +1 more source

Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress

Cell Reports
Summary: The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis.
Vera Magg, Alessandro Manetto, Katja Kopp, Chia Ching Wu, Mohsen Naghizadeh, Doris Lindner, Lucy Eke, Julia Welsch, Stefan M. Kallenberger, Johanna Schott, Volker Haucke, Nicolas Locker, Georg Stoecklin, Alessia Ruggieri   +13 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Impact of the Diversity in the 5′ UTR on Translation Regulation

WIREs RNA, Volume 17, Issue 5, September/October 2026.
Alternative transcription start site selection and alternative splicing events within the 5′ untranslated region may result in the inclusion or exclusion of translation‐initiation regulatory sequences and structures, thereby providing another layer of transcript‐selective regulation of the translation efficiency, especially in the context of stress ...
Giulia Cardamone, Melanie Flohr, Irina Bode, Tobias Schmid   +3 more
wiley   +1 more source