Results 81 to 90 of about 4,821 (166)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

eLife, 2015
Four stress-sensing kinases phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) to activate the integrated stress response (ISR).
Joseph E Chambers, Lucy E Dalton, Hanna J Clarke, Elke Malzer, Caia S Dominicus, Vruti Patel, Greg Moorhead, David Ron, Stefan J Marciniak   +8 more
doaj   +1 more source

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

eLife, 2015
Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP.
Ruming Chen, Cláudia Rato, Yahui Yan, Ana Crespillo-Casado, Hanna J Clarke, Heather P Harding, Stefan J Marciniak, Randy J Read, David Ron   +8 more
doaj   +1 more source

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells

Journal of Neuroinflammation, 2018
Background Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Zhongyuan Tan, Wanpo Zhang, Jianhong Sun, Zuquan Fu, Xianliang Ke, Caishang Zheng, Yuan Zhang, Penghui Li, Yan Liu, Qinxue Hu, Hanzhong Wang, Zhenhua Zheng   +11 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS.

PLoS ONE, 2015
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear.
Fernando G Vieira, Qinggong Ping, Andy J Moreno, Joshua D Kidd, Kenneth Thompson, Bingbing Jiang, John M Lincecum, Monica Z Wang, Gerard S De Zutter, Valerie R Tassinari, Beth Levine, Theo Hatzipetros, Alan Gill, Steven Perrin   +13 more
doaj   +1 more source

Temporal gating dictates stress-induced transcript export from the nucleus. [PDF]

Genes Dev
Helton NS, Dodd B, Moon SL.
europepmc   +1 more source

GRHAL1, a novel lncRNA, regulates HIV-1 gene expression by modulating Tat- and Sp1-mediated HIV-1 LTR activation. [PDF]

J Gen Virol
Ishaq M, Marshall H, Natarajan V.
europepmc   +1 more source

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response. [PDF]

Proc Natl Acad Sci U S A
Parenti NA, Cusic R, Renner DM, Jackson N, Ye C, Tan LH, Pfannenstiel JJ, Fehr AR, Cohen NA, Martinez-Sobrido L, Burke JM, Weiss SR.   +11 more
europepmc   +1 more source

Neuron type-specific translatomes in dorsal hippocampus during early memory consolidation. [PDF]

Nat Commun
Oliveira MM, Mosto O, Carney R, Liu WJ, Mamcarz M, Makinde E, Lu EH, Ruiz KSA, Schultz CC, Leckie C, Carew TJ, Klann E.   +11 more
europepmc   +1 more source