Results 71 to 80 of about 4,821 (166)

Capsaicin Induces ATF4 Translation with Upregulation of CHOP, GADD34 and PUMA

Biological and Pharmaceutical Bulletin, 2019
Primary Effusion Lymphoma (PEL) is a rare and aggressive B-lymphoma caused by Kaposi's sarcoma-associated herpes virus (KSHV) infection that occurs in immunocompromised patients. PEL patients have a poor prognosis. KSHV modulates various cellular signaling pathways to maintain latent infection, and causes malignant conversion of host cells.
Moriguchi, Misato, Watanabe, Tadashi, Fujimuro, Masahiro   +2 more
openaire   +3 more sources

Unraveling the Pathogenetic Mechanisms Underlying the Association between Specific Mitochondrial DNA Haplogroups and Parkinson’s Disease

Cells
Variants of mitochondrial DNA (mtDNA) have been identified as risk factors for the development of Parkinson’s disease (PD). However, the underlying pathogenetic mechanisms remain unclear.
Min-Yu Lan, Tsu-Kung Lin, Baiba Lace, Algirdas Utkus, Birute Burnyte, Kristina Grigalioniene, Yu-Han Lin, Inna Inashkina, Chia-Wei Liou   +8 more
doaj   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, Volume 293, Issue 18, Page 5585-5599, September 2026.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, Volume 293, Issue 18, Page 5627-5644, September 2026.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells

Viruses
Viruses evolve many strategies to ensure the efficient synthesis of their proteins. One such strategy is the inhibition of the integrated stress response—the mechanism through which infected cells arrest translation through the phosphorylation of the ...
Stacia M. Dolliver, Caleb Galbraith, Denys A. Khaperskyy   +2 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus

iScience, 2019
Summary: Here, we show that the US Food and Drug Administration-approved oral drug nitazoxanide (NTZ) broadly amplifies the host innate immune response to viruses and inhibits Ebola virus (EBOV) replication.
Luke D. Jasenosky, Cristhian Cadena, Chad E. Mire, Viktoriya Borisevich, Viraga Haridas, Shahin Ranjbar, Aya Nambu, Sina Bavari, Veronica Soloveva, Supriya Sadukhan, Gail H. Cassell, Thomas W. Geisbert, Sun Hur, Anne E. Goldfeld   +13 more
doaj   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

O‐Glycosylation of E‐Cadherin Induced by Endoplasmic Reticulum Stress Negatively Regulates Cell Polarity and Proliferation in Acute Kidney Injury

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ER stress could cause the O‐glycosylation of E‐cadherin in RTECs, leading to dysregulation of cell polarity and proliferation. ER stress inhibitors alleviate kidney injury and promote the recovery of kidney function. These findings provide new molecular targets and intervention strategies for the clinical treatment of AKI. ABSTRACT The loss of polarity
Yingjia Zhang, Weidong Zhang, Qingwu Liao, Zhaoxing Sun, Weize Chen, Xiaoqiang Ding, Shuan Zhao   +6 more
wiley   +1 more source

Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections

Frontiers in Immunology, 2019
The guanabenz derivative Sephin1 has recently been proposed to increase the levels of translation initiation factor 2 (eIF2α) phosphorylation by inhibiting dephosphorylation by the protein phosphatase 1—GADD34 (PPP1R15A) complex.
Maxime Fusade-Boyer, Gabriel Dupré, Pierre Bessière, Samira Khiar, Charlotte Quentin-Froignant, Charlotte Quentin-Froignant, Cécile Beck, Sylvie Lecollinet, Marie-Anne Rameix-Welti, Marie-Anne Rameix-Welti, Jean-François Eléouët, Frédéric Tangy, Barbora Lajoie, Stéphane Bertagnoli, Pierre-Olivier Vidalain, Franck Gallardo, Romain Volmer   +16 more
doaj   +1 more source