Results 31 to 40 of about 363,972 (179)
, 2015 Scheme of PERK dependent eIF2α phosphorylation and the principle of LanthaScreen detection of p-eIF2α.
William E. Wixted (703659) +13 more
core +1 more source
Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease
Frontiers in Molecular Neuroscience, 2014 Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of eukaryotic initiation factor-2α (eIF2α). Evidence is accumulating that persistent eIF2α phosphorylation at Ser51 through prolonged overactivation of ...
Masuo eOhno, Masuo eOhno
doaj +1 more source
Increased eIF2α phosphorylation in response to rapamycin:
, 2013 a. Cells were incubated for 24 hours with 50 nM rapamycin, harvested and processed for determination of changes in eIF2α phosphorylation b. Mean ± SEM fold change relative to control of eIF2α (e), p-eIF2α (p) and the ratio p-eIF2α/eIF2α (p/e) in ...
Liron Tuval-Kochen (476856) +9 more
core +1 more source
Cell Reports, 2012 Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK). To examine the role of PERK in cognitive function, we selectively disrupted PERK expression in the adult mouse forebrain.
Mimi A. Trinh +5 more
doaj +1 more source
Cell Death Discovery, 2022 GSDMD is the key effector of pyroptosis, but its non-pyroptosis-related functions have seldom been reported. Here, we report that GSDMD is overexpressed in different types of tumours, including head and neck squamous-cell carcinoma, and it promotes the ...
Qianyu Zhang +14 more
doaj +1 more source
Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation. [PDF]
J Cell Biol, 2017 Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism specifically impact neuronal intracellular processes and cause neuropathological events is still ...
Tsuyama T +4 more
europepmc +2 more sources
Salubrinal enhances radiation induced eIF2α phosphorylation:
, 2013 a. Cells were processed for analysis of eIF2α phosphorylation 48 hours post-addition of salubrinal (Sal). b. Mean ± SEM fold change relative to control of eIF2α (e), p-eIF2α (p) and of the ratio p-eIF2α/eIF2α (p/e) in salubrinal (Sal) treated cells.
Liron Tuval-Kochen (476856) +9 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Aquatic birnavirus-induced ER stress-mediated death signaling contribute to downregulation of Bcl-2 family proteins in salmon embryo cells. [PDF]
PLoS ONE, 2011 Aquatic birnavirus induces mitochondria-mediated cell death, but whether connects to endoplasmic reticulum (ER) stress is still unknown. In this present, we characterized that IPNV infection triggers ER stress-mediated cell death via PKR/eIF2α ...
Hui Ling Huang +3 more
doaj +1 more source
Increased eIF2α phosphorylation in response to radiation:
, 2013 a. MCF-7 and b. MDA-MB-231 cells were irradiated with the indicated radiation dose and processed for analysis of eIF2α phosphorylation at the noted time post-irradiation. c.
Liron Tuval-Kochen (476856) +9 more
core +1 more source