Results 51 to 60 of about 363,972 (179)

Pharmacological brake-release of mRNA translation enhances cognitive memory

eLife, 2013
Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating a ...
Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter   +17 more
doaj   +1 more source

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

Eukaryotic initiation factor 2α phosphorylation is required for B-cell maturation and function in mice

Haematologica, 2011
Background The control of translation initiation is a crucial component in the regulation of gene expression. The eukaryotic initiation factor 2α (eIF2α) mediates binding of the initiator transfer-messenger-RNA to the AUG initiation codon, and thus ...
Nina Mielke, Rolf Schwarzer, Cornelis F. Calkhoven, Randal J. Kaufman, Bernd Dörken, Achim Leutz, Franziska Jundt   +6 more
doaj   +1 more source

Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4

Life Science Alliance, 2021
Differentiated dendritic cells display an unusual activation of the integrated stress response, which is necessary for normal type-I Interferon production and cell migration.
Andreia Mendes, Julien P Gigan, Christian Rodriguez Rodrigues, Sébastien A Choteau, Doriane Sanseau, Daniela Barros, Catarina Almeida, Voahirana Camosseto, Lionel Chasson, Adrienne W Paton, James C Paton, Rafael J Argüello, Ana-Maria Lennon-Duménil, Evelina Gatti, Philippe Pierre   +14 more
doaj   +1 more source

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

, 2009
SummaryAccumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on Ser51 of the α subunit (eIF2α).
Back, Sung Hoon, Song, Benbo, Kaufman, Randal J., Gildersleeve, Robert D., Scheuner, Donalyn, Ribick, Mark, Pennathur, Subramaniam, Han, Jaeseok, Wang, Junying   +8 more
core   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Hypothalamic eIF2α Signaling Regulates Food Intake

Cell Reports, 2014
The reversible phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) is a highly conserved signal implicated in the cellular adaptation to numerous stresses such as the one caused by amino acid limitation.
Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol, Xavier Brenachot, Laurent Parry, Valérie Carraro, Christophe Guissard, Julien Averous, Céline Jousse, Alain Bruhat, Cédric Chaveroux, Wafa B’chir, Yuki Muranishi, David Ron, Luc Pénicaud, Pierre Fafournoux   +15 more
doaj   +1 more source

A GCN2-Like eIF2α Kinase (LdeK1) of Leishmania donovani and Its Possible Role in Stress Response. [PDF]

PLoS ONE, 2016
Translation regulation in Leishmania parasites assumes significance particularly because they encounter myriad of stresses during their life cycle. The eukaryotic initiation factor 2α (eIF2α) kinases, the well-known regulators of translation initiation ...
Shilpa J Rao, Shimi Meleppattu, Jayanta K Pal   +2 more
doaj   +1 more source

The eIF2α kinase HRI is responsible for nsPEF-induced eIF2α phosphorylation.

, 2020
(A) Various stressors phosphorylate eIF2α via activation of four eIF2α kinases, PERK, GCN2, HRI and PKR. (B) Representative immunoblots of phosphorylated eIF2α and total eIF2α in WT and 4KO MEF cells 1 h after nsPEF treatment (40 shots of 70-ns duration ...
Yoshimasa Hamada (8555628), Shusuke Taniuchi (8555637), Yuji Furumoto (8555631), Kenji Teranishi (8555640), Akira Izutani (8555634), Masato Miyake (818680), Seiichi Oyadomari (623781), Miho Oyadomari (4170271), Naoyuki Shimomura (8555643)   +8 more
core   +1 more source

Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in [PDF]

, 2017
Cell-nonautonomous effects of signaling in the nervous system of animals can influence diverse aspects of organismal physiology. We previously showed that phosphorylation of Ser49 of the α-subunit of eukaryotic translation initiation factor 2 (eIF2α) in ...
Ying K Zhang, Kim, Dennis H., Warakorn Kulalert, Schroeder, Frank C., Zhang, Ying K., Dennis H Kim, Kulalert, Warakorn, Sadeeshkumar, Harini, Harini Sadeeshkumar, Frank C Schroeder   +9 more
core   +1 more source