Results 61 to 70 of about 363,972 (179)

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Phosphorylation of eIF2α suppresses the impairment of GSH/NADPH homeostasis and mitigates the activation of cell death pathways, including ferroptosis, during ER stress

Molecules and Cells
: eIF2α Phosphorylation helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional and translational reprogramming.
Hien Thi Le, Yonghwan Kim, Mi-Jeong Kim, Seung Hwa Hyun, Hyeeun Kim, Su Wol Chung, Yeonsoo Joe, Hun Taeg Chung, Dong-Myung Shin, Sung Hoon Back   +9 more
doaj   +1 more source

Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response

Cell Death and Disease, 2021
The integrated stress response manifests with the phosphorylation of eukaryotic initiation factor 2α (eIF2α) on serine residue 51 and plays a major role in the adaptation of cells to endoplasmic reticulum stress in the initiation of autophagy and in the ...
Ai-Ling Tian, Qi Wu, Peng Liu, Liwei Zhao, Isabelle Martins, Oliver Kepp, Marion Leduc, Guido Kroemer   +7 more
doaj   +1 more source

Serine Threonine Kinase STK-10 Is Necessary for Rhythmic Phosphorylation of Eukaryotic Translation Initiation Factor eIF2α [PDF]

, 2022
The circadian clock is a conserved endogenous time keeping mechanism that controls up to half of the eukaryotic genome at the level of transcript abundance.
Ramirez, Manuel Antonio
core  

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. [PDF]

PLoS ONE, 2012
6-Shogaol is an active compound isolated from Ginger (Zingiber officinale Rosc). In this work, we demonstrated that 6-shogaol induces apoptosis in human hepatocellular carcinoma cells in relation to caspase activation and endoplasmic reticulum (ER ...
Rong Hu, Ping Zhou, Yong-Bo Peng, Xiaojun Xu, Jiang Ma, Qun Liu, Lei Zhang, Xiao-Dong Wen, Lian-Wen Qi, Ning Gao, Ping Li   +10 more
doaj   +1 more source

Phosphorylation of eIF2α.

, 2014
Insulinoma cells were treated with palmitate (500 µM) alone or together with metformin (10 µM, 100 µM) at 70–80% confluence. Cell lysates were prepared after 8 h and the phosphorylation and expression level of eIF2α were assessed by Western blot analysis
Márton Kokas (572560), József Mandl (572561), Miklós Csala (572562), Laura Simon-Szabó (572559), György Kéri (2517313)   +4 more
core   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

Stress-induced inhibition of translation independently of eIF2α phosphorylation [Elektronisk resurs]

, 2015
Exposure of fission yeast cells to ultraviolet (UV) light leads to inhibition of translation and phosphorylation of the eukaryotic initiation factor-2α (eIF2α). This phosphorylation is a common response to stress in all eukaryotes. It leads to inhibition
Rødland, Gro Elise, Håland, Tine Weise, Boye, Erik, Knutsen, Jon Halvor, Sunnerhagen, Per,, Grallert, Beata, Bøe, Cathrine Arnason   +6 more
core   +1 more source

Coordinate regulation of eif2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development [PDF]

, 2020
Phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by the kinase GCN2 attenuates protein synthesis during amino acid starvation in yeast, whereas in mammals a family of related eIF2α kinases regulate translation in response to a ...

core   +2 more sources