Results 81 to 90 of about 363,972 (179)

Combined treatment of salubrinal and Vorinostat increases eIF2α phosphorylation:

, 2013
a. Cells were harvested 48 hours following application of the vehicle (D), 4.5 µM salubrinal (S), 0.75 µM Vorinostat (V) or both (V+S) and processed for Western blot analysis of eIF2α phosphorylation. b. Mean fold change relative to control of eIF2α (e),
Liron Tuval-Kochen (476856), Charles Nakar (476859), Tamar Golani (476860), Shoshana Paglin (476857), Yaniv Lerenthal (476858), Joachim Yahalom (476861), Gilmor Keshet (247078), Yaacov Lawrence (476863), Raphael Pfeffer (476862), Amos Toren (267124)   +9 more
core   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species.

PLoS Pathogens, 2016
Entamoeba histolytica is an enteric pathogen responsible for amoebic dysentery and liver abscess. It alternates between the host-restricted trophozoite form and the infective environmentally-stable cyst stage. Throughout its lifecycle E.
Holland M Hendrick, Brenda H Welter, Matthew A Hapstack, Steven E Sykes, William J Sullivan, Lesly A Temesvari   +5 more
doaj   +1 more source

Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

eLife, 2016
Adolescents are especially prone to drug addiction, but the underlying biological basis of their increased vulnerability remains unknown. We reveal that translational control by phosphorylation of the translation initiation factor eIF2α (p-eIF2α ...
Wei Huang, Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Carmela Sidrauski, Krešimir Krnjević, Peter Walter, John A Dani, Mauro Costa-Mattioli   +8 more
doaj   +1 more source

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells

Viruses
Viruses evolve many strategies to ensure the efficient synthesis of their proteins. One such strategy is the inhibition of the integrated stress response—the mechanism through which infected cells arrest translation through the phosphorylation of the ...
Stacia M. Dolliver, Caleb Galbraith, Denys A. Khaperskyy   +2 more
doaj   +1 more source

GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2020
The integrated stress response in eukaryotic cells is an orchestrated pathway that leads to eukaryotic Initiation Factor 2 alpha subunit (eIF2α) phosphorylation at ser51 and ultimately activates pathways to mitigate cellular damages.
Amaranta Muniz Malvezzi, Mirella Aricó, Normanda Souza-Melo, Gregory Pedroso dos Santos, Paula Bittencourt-Cunha, Fabiola Barbieri Holetz, Sergio Schenkman   +6 more
doaj   +1 more source

Titration of GFP-eIF2α BacMam.

, 2015
(A) U-2 OS cells were mixed with different amount of GFP-eIF2α BacMam and plated to a 384 well culture plate for overnight. Cells were then treated with either DMSO or 2 μM Tg for 1 h at 37°C 5% CO2.
William E. Wixted (703659), Wensheng Xie (703657), Roberto Solari (112167), Alan Diehl (703666), Maggie Truong (703662), Hu Li (130600), Yolanda Sanchez (213896), Christina Pao (703663), James Callahan (703665), Robert S. Ames (703664), Nilesh Chitnis (703660), Marie Pariollaud (703658), Yan Liu (25061), James Fornwald (703661)   +13 more
core   +1 more source

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling

Molecular Microbiology, EarlyView.
Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley   +1 more source