Results 101 to 110 of about 363,972 (179)

The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609

Journal of Lipid Research, 2004
The cytotoxic effects of several chemotherapeutic drugs have been linked to elevated de novo ceramide biosynthesis. However, the relationship between the intracellular site(s) of ceramide accumulation and cytotoxicity is poorly understood.
Ryan J. Perry, Neale D. Ridgway
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Adaptive Basal Phosphorylation of eIF2α Is Responsible for Resistance to Cellular Stress–Induced Cell Death in Pten-Null Hepatocytes

, 2011
The α-subunit of eukaryotic initiation factor 2 (eIF2α) is a key translation regulator that plays an important role in cellular stress responses. In the present study, we investigated how eIF2α phosphorylation can be regulated by a tumor suppressor PTEN (
Xiaoling Xu, Yang Li, Vivian Galicia, Chuxia Deng, Bangyan L. Stiles, Ni Zeng, Lina He   +6 more
core   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, Volume 104, Issue 10, Page 975-986, November‐December 2026.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

15-Deoxyspergualin inhibits eukaryotic protein synthesis through eIF2α phosphorylation

, 2007
DSG (15-deoxyspergualin), an immunosuppressant with tumoricidal properties, binds potently to the regulatory C-terminal 'EEVD' motif of Hsps (heat-shock proteins).
Surolia, Avadhesha, Ramya, T. N. C., Surolia, Namita   +2 more
core   +1 more source

AAV vectors efficiently transduce primary neurons and block eIF2α phosphorylation with minimal toxicity.

, 2014
(A) A two-vector adeno-associated virus (AAV) system was used to decrease eIF2α phosphorylation specifically in excitatory forebrain neurons. The “activator” vector (CaMKII tTA-AAV) expresses the tetracycline transactivator (tTA) protein from a ...
Pavel Osten (75265), William A. Eimer (592399), Robert Vassar (38951), Randal J. Kaufman (561534), Katherine R. Sadleir (592398)   +4 more
core   +1 more source

PERK inhibition mitigates acrylamide-induced tau phosphorylation and synaptic deficits via the GSK-3β and ATF4 pathways in human neuroblastoma SH-SY5Y cells

Ecotoxicology and Environmental Safety
Acrylamide (ACR), a potential neurotoxin prevalent in carbohydrate-rich foods, poses a significant public health concern. While ACR exposure is known to induce tau phosphorylation and synaptic impairment, the underlying mechanisms remain incompletely ...
Dandan Yan, Yang Jiao, Xing Zhang, Hong Yan   +3 more
doaj   +1 more source

Ribosomal stalk proteins stimulate the phosphorylation of eIF2α by GCN2 kinase in vitro.

, 2013
(A) Increasing amounts of a P1/P2 ribosomal extract (SP fraction) from either wild-type W303-1b (WT) or mutant D4567 were added to a phosphorylation assay containing purified eIF2α and GCN2 kinase.
Juan José Berlanga (125208), Antonio Jiménez-Díaz (503980), Juan P. G. Ballesta (503981), Miguel Remacha (11427)   +3 more
core   +1 more source

SAMHD1 modulates the phosphorylation of eIF2α and the interaction of eIF4G and eIF4A.

, 2015
(A) Effect of SAMHD1 on eIF2α phosphorylation. HEK-293T cells were transfected with Myc-SAMHD1 or Myc-G3BP1 cDNA. Cells were also treated with arsenite (AS, 500 μM) for 0.5 hour that is known to induce eIF2α phosphorylation.
Siqi Hu (188357), Qi Jin (12159), Lijuan Yin (764679), Shan Mei (351116), Fei Guo (181055), Chen Liang (196452), Yann Le Duff (764678), Jian Li (41607), Fengwen Xu (764677), Shan Cen (107285), Xiaojing Pang (550263)   +10 more
core   +1 more source

Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease

Neural Plasticity, 2015
Alzheimer’s disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α (eIF2α) at serine 51. Increased phosphorylation of eIF2α alters translational control and may thereby have adverse effects on synaptic ...
Katharina Paesler, Kan Xie, Moritz M. Hettich, Magdalena E. Siwek, Devon P. Ryan, Susanne Schröder, Anna Papazoglou, Karl Broich, Ralf Müller, Astrid Trog, Alexander Garthe, Gerd Kempermann, Marco Weiergräber, Dan Ehninger   +13 more
doaj   +1 more source