Results 91 to 100 of about 363,972 (179)

eIF2α controls memory consolidation via excitatory and somatostatin neurons

, 2020
An important tenet of learning and memory is the notion of a molecular switch that promotes the formation of long-term memory1,2,3,4. The regulation of proteostasis is a critical and rate-limiting step in the consolidation of new memories5,6,7,8,9,10 ...
Cohen, Noah, Stokes, Matthew P., Hung, Tzu-Yu, Possemato, Anthony P., Eslamizade, Mohammad Javad, Khlaifia, Abdessattar, Quintana, Albert, Rosenblum, Kobi, Cuello, A. Claudio, Sanz, Elisenda, Lalzar, Maya, Lacaille, Jean-Claude, Sonenberg, Nahum, Abell, Kathryn, Sharma, Vijendra, Wang, Peng, Kaufman, Randal J., Khoutorsky, Arkady, Asgarihafshejani, Azam, Costa-Mattioli, Mauro, Truong, Vinh T., Lou, Danning, Kiniry, Stephen J., Sood, Rapita, Nader, Karim, Baranov, Pavel V., Gal-Ben-Ari, Shunit, Saffarzadeh, Fatemeh, Nelson, Alissa J., Yiannakas, Adonis, Stephen J. Kiniry, Jean-Claude Lacaille, Elisenda Sanz, A. Claudio Cuello, Vijendra Sharma, Kathryn Abell, Peng Wang, Mohammad Javad Eslamizade, Adonis Yiannakas, Danning Lou, Alissa J. Nelson, Arkady Khoutorsky, Tzu-Yu Hung, Azam Asgarihafshejani, Rapita Sood, Matthew P. Stokes, Albert Quintana, Noah Cohen, Shunit Gal-Ben-Ari, Mauro Costa-Mattioli, Pavel V. Baranov, Vinh T. Truong, Abdessattar Khlaifia, Karim Nader, Anthony P. Possemato, Randal J. Kaufman, Maya Lalzar, Nahum Sonenberg, Fatemeh Saffarzadeh, Kobi Rosenblum   +59 more
core   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

PfeIK1, a eukaryotic initiation factor 2α kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation

Malaria Journal, 2009
Background Post-transcriptional control of gene expression is suspected to play an important role in malaria parasites. In yeast and metazoans, part of the stress response is mediated through phosphorylation of eukaryotic translation initiation factor 2α
Ranford-Cartwright Lisa, Wilkes Jonathan, Russo Ilaria, Babbitt Shalon, Fennell Clare, Goldberg Daniel E, Doerig Christian   +6 more
doaj   +1 more source

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, Volume 46, Issue 12, Page 4782-4798, December 2026.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source

Mammalian Orthoreovirus Escape from Host Translational Shutoff Correlates with Stress Granule Disruption and Is Independent of eIF2α Phosphorylation and PKR

, 2011
In response to mammalian orthoreovirus (MRV) infection, cells initiate a stress response that includes eIF2α phosphorylation and protein synthesis inhibition.
Craig Hastings, Qingsong Qin, Cathy L. Miller, Kate Carroll   +3 more
core   +1 more source

Shikonin: From Biosynthesis and Pharmacological Mechanisms to Translational Safety and Drug Delivery

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Shikonin, biosynthesised in Boraginaceae roots from phenylalanine‐derived PHB and isoprenoid GPP, modulates redox balance, cellular stress, signalling pathways, and regulated cell death. Preclinical studies support diverse pharmacological activities, while nanocarriers improve dispersion and delivery.
Namini Joshi, Prabhakar Semwal, Balwant Rawat, Ravendra Kumar, Mozaniel Santana de Oliveira, Nishant Rai, Janhvi Mishra Rawat   +6 more
wiley   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, Volume 13, Issue 61, 3 November 2026.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, Volume 40, Issue 11, Page 6490-6515, November 2026.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

eIF2α signaling regulates autophagy of osteoblasts and the development of osteoclasts in OVX mice [PDF]

, 2019
Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 ...
Liu, Daquan, Na, Sungsoo, Li, Xinle, Li, Jie, Yokota, Hiroki, Wan, Qiaoqiao, Hamamura, Kazunori, Zhang, Ping, Jie Li, Xinle Li, Kazunori Hamamura, Ping Zhang, Daquan Liu, Qiaoqiao Wan, Hiroki Yokota, Sungsoo Na   +15 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, Volume 40, Issue 11, Page 6535-6552, November 2026.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source