Results 111 to 120 of about 363,972 (179)

LINP1 represses unfolded protein response by directly inhibiting eIF2α phosphorylation to promote cutaneous squamous cell carcinoma. [PDF]

Exp Hematol Oncol, 2023
Liang X, Liu J, Liu X, Jin Y, Xu M, Han Z, Wang K, Zhang C, Zou F, Zhou L.   +9 more
europepmc   +1 more source

Porcine Reproductive and Respiratory Syndrome Virus Infection Induces both eIF2α Phosphorylation-Dependent and -Independent Host Translation Shutoff

, 2018
Viruses are obligate parasites, and the production of progeny viruses relies strictly on the host translation machinery. Therefore, the efficient modulation of host mRNA translation benefits viral replication, spread, and evolution.
Dang Wang, Yang Li, Ran Tao, Yanrong Zhou, Shaobo Xiao, Liurong Fang   +5 more
core   +1 more source

Mitochondrial Inhibition by Sodium Azide Induces Assembly of eIF2α Phosphorylation-Independent Stress Granules in Mammalian Cells. [PDF]

Int J Mol Sci, 2022
Eiermann N, Stoecklin G, Jovanovic B.
europepmc   +1 more source

In primary neurons, genetic reduction of eIF2α phosphorylation via eIF2α S51A knockin mutation does not inhibit BACE1 and APP elevation in response to Aβ42 oligomer treatment.

, 2014
Mixed cortical primary neurons were isolated from e15.5 mouse embryos that were either homozygous for the eIF2α S51A targeted replacement mutation (A/A) or heterozygous (S/A).
Pavel Osten (75265), William A. Eimer (592399), Robert Vassar (38951), Randal J. Kaufman (561534), Katherine R. Sadleir (592398)   +4 more
core   +1 more source

Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation. [PDF]

Proc Natl Acad Sci U S A, 2022
Sehrawat U, Haimov O, Weiss B, Tamarkin-Ben Harush A, Ashkenazi S, Plotnikov A, Noiman T, Leshkowitz D, Stelzer G, Dikstein R.   +9 more
europepmc   +1 more source

Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer. [PDF]

Cell Death Dis, 2021
Guo B, Xiong X, Hasani S, Wen YA, Li AT, Martinez R, Skaggs AT, Gao T.   +7 more
europepmc   +1 more source

Genetic reduction of eIF2α phosphorylation via eIF2α S51A knockin mutation does not block amyloid-associated BACE1 elevation in 5XFAD brain.

, 2014
5XFAD mice were crossed with mice harboring the eIF2α S51A targeted replacement mutation to generate 5XFAD (+) or non-Tg (–) offspring that were either heterozygous for the eIF2α S51A knockin mutation (S/A) or wild-type (S/S). Mice were aged to 12 months,
Pavel Osten (75265), William A. Eimer (592399), Robert Vassar (38951), Randal J. Kaufman (561534), Katherine R. Sadleir (592398)   +4 more
core   +1 more source

BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation. [PDF]

Gastroenterology, 2022
Li Z, Ge Y, Dong J, Wang H, Zhao T, Wang X, Liu J, Gao S, Shi L, Yang S, Huang C, Hao J.   +11 more
europepmc   +1 more source

Consolidation of object recognition memory requires HRI kinase‐dependent phosphorylation of eIF2α in the hippocampus

, 2013
Local control of protein synthesis at synapses is crucial for synaptic plasticity and memory formation. However, little is known about the signals coupling neurotransmitter release with the translational machinery during these processes. Here, we studied
Gerard ILL‐Raga, ILL-Raga, Gerard, Mark D. Rosen, Lima, Ramón H., Cammarota, Martín Pablo, Cristiano Köhler, Ramón H. Lima, Radiske, Andressa, Andressa Radiske, Martín Cammarota, Francisco J. Muñoz, Kohler, Cristiano, Rosen, Mark D., Muñoz, Francisco J.   +13 more
core   +1 more source

The heme-regulated inhibitor kinase Hri1 is activated in response to aminolevulinic acid deficiency in Schizosaccharomyces pombe.

PLoS Genetics
A key mechanism for regulating the initiation of protein synthesis in response to various stresses involves the phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α).
Samuel Plante, Ariane Brault, Mariano Avino, Hajer Sakouhi, Florie Lo Ying Ping, Tobias Vahsen, Simon Labbé   +6 more
doaj   +1 more source