Results 81 to 90 of about 30,951 (226)

An Islamic Perspective on the Sustainable Development Goals: Exploring Key Challenges From the Ravi Riverfront Urban Development Project

Sustainable Development, EarlyView.
ABSTRACT Projects are typically viewed as mechanisms for delivering products and services; however, this study examines projects from the distinct perspective of grand challenges (GCs). The selected case is the Ravi Riverfront Urban Development Project in Lahore, Pakistan—a grand challenge project (GCP).
Rehab Iftikhar, Syed Nayyer Abbas Kazmi
wiley   +1 more source

Deciphering the multifaceted role of double-stranded RNA sensor protein kinase R: pathophysiological function beyond the antiviral response

RNA Biology
Protein kinase R (PKR) is a serine/threonine kinase that recognizes double-stranded RNAs (dsRNAs) to initiate innate immune signalling during viral infection. PKR dimerizes on long dsRNAs and undergoes autophosphorylation.
Jiyoon Chung, Yerim Lee, Jimin Yoon, Yoosik Kim   +3 more
doaj   +1 more source

dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication

Frontiers in Cellular and Infection Microbiology, 2017
Enterovirus 71 (EV-A71) causes hand, foot and mouth disease in young children and infants, but can also cause severe neurological complications or even death.
Yu-Hsiu Chang, Yu-Hsiu Chang, Kean Seng Lau, Rei-Lin Kuo, Rei-Lin Kuo, Jim-Tong Horng, Jim-Tong Horng, Jim-Tong Horng, Jim-Tong Horng, Jim-Tong Horng   +9 more
doaj   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

greenkidneybean/dms_human-pkr: Upload Supplemental Files

Deep mutational scan of Human PKR under pseudosubstrate antagonism by vaccinia ...
Michael Chambers
core   +1 more source

PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

Nature Communications
The innate immune sensor PKR for double-stranded RNA (dsRNA) is critical for antiviral defense, but its aberrant activation by cellular dsRNA is linked to various diseases.
Sadeem Ahmad, Tao Zou, Jihee Hwang, Linlin Zhao, Xi Wang, Anton Davydenko, Ilana Buchumenski, Patrick Zhuang, Alyssa R. Fishbein, Diego Capcha-Rodriguez, Aaron Orgel, Erez Y. Levanon, Sua Myong, James Chou, Matthew Meyerson, Sun Hur   +15 more
doaj   +1 more source

Penetration Resistance: PKR's Other Talent [PDF]

Immunity, 2012
In this issue of Immunity, Irving et al. (2012) show that protein kinase R (PKR) regulates the cytoskeleton via an interaction with gelsolin. This alternative role for PKR prevents penetration of virions into the cell.
Lacy-Hulbert, Adam, Stuart, Lynda M.
openaire   +2 more sources

EMIGRE CITY‐MAKING: The Micropolitics of Diasporic Real Estate Investment and Urban Growth in Pakistan

International Journal of Urban and Regional Research, EarlyView.
Abstract Contemporary cities in the global South are being reshaped through the intersecting logics of burgeoning real estate sectors and diasporic investment. This article examines the case of Pakistan to explore how emigration trajectories and remittance practices contribute to the transformation of urban landscapes in countries of origin through ...
Fatima Tassadiq
wiley   +1 more source

Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA

Nature Communications
Double-stranded RNAs (dsRNAs) produced during viral infections are recognized by the innate immune sensor protein kinase R (PKR), triggering a host translation shutoff that inhibits viral replication and propagation.
Lavanya Manjunath, Gisselle Santiago, Pedro Ortega, Ambrocio Sanchez, Sunwoo Oh, Alexander Garcia, Junyi Li, Dana Duong, Elodie Bournique, Alexis Bouin, Bert L. Semler, Dheva Setiaputra, Rémi Buisson   +12 more
doaj   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source