Results 101 to 110 of about 30,951 (226)
Antiviral functions of PKR and PKZ in crucian carp (Carassius auratus L.)
, 2011 当细胞受到病毒感染时，依赖于双链RNA（dsRNA）的蛋白激酶（PKR）通过磷酸化真核翻译起始因子2α（eIF2α）广谱性地阻断蛋白翻译来实现抑制病毒复制的目的。在某些鱼类，除表达PKR外，还表达一个与PKR-like激酶PKZ，该蛋白的N端包含两个Z-DNA结合结构域而不是两个存在于PKR蛋白N端的dsRNA结合结构域。然而，在干扰素（IFN）介导的抗病毒免疫反应中，鱼类PKZ扮演何种角色以及PKR与PKZ之间的相互作用仍不清楚。本研究发现PKR和PKZ共存于鲫基因组中 ...
刘庭凯
core
PKR inhibition prevents C/EBPβ and eIF4B expression.
, 2018 (A) THP-1 cells were incubated with PMA ± 1 μM PKR inhibitor (PKR-I) up to 24 h, and the levels of LAP*/LAP were determined (n = 3). (B) THP-1 cells were incubated ± PMA up to 24 h, and the levels of LAP*/LAP, (p-)PKR, and (p-)eIF2α were measured (n = 3).
Andreas Westphal (578429) +7 more
core +1 more source
Public Health Challenges, Volume 5, Issue 4, December 2026.A cross‐sectional study of 384 school‐going adolescents in peri‐urban South Punjab, Pakistan, found a high prevalence of severe household food insecurity (95.1%), including thinness, stunting, and overweight/obesity. These findings underscore the need for school‐based nutrition interventions and policies supporting Sustainable Development Goal 2 ...
Rameesha Shauket +2 more
wiley +1 more source
, 2013 SH-SY5Y cells were infected with HSV1 (1 pfu/cell, 24 h) or were not infected (controls). Immunocytochemistry analysis was carried with the following Abs: anti-p-PKR, anti-p-eIF2-alpha and anti-BACE1 (A).
Francesc X. Guix (349265) +14 more
core +1 more source
Activation of the Antiviral Kinase PKR and Viral Countermeasures [PDF]
, 2009 The interferon-induced double-stranded (ds)RNA-dependent protein kinase (PKR) limits viral replication by an eIF2α-mediated block of translation. Although many negative-strand RNA viruses activate PKR, the responsible RNAs have long remained elusive, as ...
Dauber, Bianca +3 more
core +1 more source
Health Expectations, Volume 29, Issue 6, December 2026.ABSTRACT Background The co‐occurrence of diabetes and tuberculosis (TB) worsens outcomes for both conditions, increasing mortality risk and treatment failure. Despite the need for integrated care for the two conditions, evidence on feasible and context‐specific implementation strategies remains limited.
Saima Afaq +12 more
wiley +1 more source
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, Volume 13, Issue 61, 3 November 2026.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
PKR mRNA levels are correlated with PKR protein levels in primary NSCLC tissues.
, 2013 A. Western blot analysis of PKR and p-PKR protein in tumor samples. A densitometric analysis of the ratio of PKR or PKR to β-actin is represents normalized protein levels. Each lane represents a tumor sample from an individual patient. B.
Apar Pataer (184395) +11 more
core +1 more source
PKR's protective role in viral myocarditis
Virology, 2003 Reovirus-induced murine myocarditis provides an excellent model for the human disease. Previously, we showed that reovirus induction of and sensitivity to interferon-beta (IFN-beta) are important determinants of protection against cardiac damage. IFN-beta induces a number of genes with antiviral activities, including the dsRNA-activated protein kinase,
Stewart, Michael J +2 more
openaire +2 more sources
Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production
Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3152-3164, November 2026.ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise +3 more
wiley +1 more source