Results 121 to 130 of about 30,951 (226)
Double-stranded RNA-dependent protein kinase regulates the motility of breast cancer cells.
PLoS ONE, 2012 Double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is an interferon-induced protein kinase that plays a central role in the anti-viral process.
Mei Xu +8 more
doaj +1 more source
The Cytokine Response of Circulating Immune Cells to Rhinovirus (RV‐A16) is Reduced in Severe Asthma
Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.ABSTRACT Severe asthma patients (SA) are more susceptible to respiratory infections with human rhinoviruses (HRV) than healthy subjects (H), causing exacerbations. In response to HRV, circulating immune cells are recruited to and activated at the local sites of infection.
Kaschin Jamal Jameel +10 more
wiley +1 more source
, 2017 SHAH ALAM PKR menjadi parti paling rugi dengan terputusnya tahaluf siyasi bersama Pas. Pensyarah Universiti Utara Malaysia (UUM), Md Shukri Shuib berkata, ini kerana PKR kebiasaannya mengharap undi kaum Cina atau DAP, dan juga undi akar umbi ...
Sinar, Harian
core +1 more source
The FASEB Journal, Volume 40, Issue 19, 15 October 2026.Mmp‐8 deficiency during H1N1 influenza infection enhances Type I interferon responses, necroptosis‐associated signaling, and adaptive immunity, leading to lower lung viral burden and improved survival, but also amplifies inflammatory lung injury. ABSTRACT Matrix metalloproteinase‐8 (MMP‐8) regulates inflammatory responses, but its contributions to the ...
Xiaoyun Wang +4 more
wiley +1 more source
コツガ サイボウ ノ ブンカ ニオケル PKR ノ ヤクワリ ニツイテ [PDF]
, 2008 In this study, it was demonstrated that double-stranded RNA-dependent protein kinase (PKR) is required for the differentiation of osteoblasts. PKR was expressed on the surface of trabecula in rat tibiae.
ヨシダ, カヤ +5 more
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, 2013 (A) An autoradiograph (32P; on the left) and Western blot (WB; on the right) showing electrophoretically separated proteins labeled with 32P by PKR in a kinase assay, or probed with a rabbit anti-RHA antibody, respectively.
Anthony J. Sadler (374383) +4 more
core +1 more source
KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.
PLoS Pathogens, 2017 TIA-1 positive stress granules (SG) represent the storage sites of stalled mRNAs and are often associated with the cellular antiviral response. In this report, we provide evidence that Kaposi's sarcoma-associated herpesvirus (KSHV) overcomes the host ...
Nishi R Sharma +3 more
doaj +1 more source
Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity
, 2012 In a screen designed to identify novel inducers of autophagy, we discovered that STAT3 inhibitors potently stimulate the autophagic flux. Accordingly, genetic inhibition of STAT3 stimulated autophagy in vitro and in vivo, while overexpression of STAT3 ...
Kepp, Oliver +33 more
core +1 more source
Activation of PKR by a short-hairpin RNA
Scientific ReportsRecognition of viral infection often relies on the detection of double-stranded RNA (dsRNA), a process that is conserved in many different organisms. In mammals, proteins such as MDA5, RIG-I, OAS, and PKR detect viral dsRNA, but struggle to differentiate between viral and endogenous dsRNA. This study investigates an shRNA targeting DDX54's potential to
Cottrell, Kyle A +7 more
openaire +4 more sources
Binding and Relocalization of PKR 1 by Murine Cytomegalovirus [PDF]
, 2009 Many viruses have evolved mechanisms to evade the repression of translation mediated by protein kinase R (PKR). In the case of murine cytomegalovirus (MCMV), the protein products of two essential genes, m142 and m143, bind to dsRNA and block ...
Child, Stephanie J., Geballe, Adam P.
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