Results 131 to 140 of about 30,951 (226)

Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes [PDF]

European Cells & Materials, 2012
This study investigated whether treatment of articular cartilage chondrocytes with a combination of oncostatin M (OSM) and interleukin-1 (IL-1) could induce a degradative phenotype that was mediated through the protein kinase R (PKR) signalling pathway ...
SJ Gilbert, EJ Blain, A Al-Sabah, Y Zhang, VC Duance, DJ Mason   +5 more
doaj  

The Role of PKR/eIF2 alpha Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer [PDF]

, 2011
BackgroundIn this study, we investigated whether PKR protein expression is correlated with mRNA levels and also evaluated molecular biomarkers that are associated with PKR, such as phosphorylated PKR (p-PKR) and phosphorylated eIF2α (p-eIF2α).Methodology
Hofstetter, Wayne L., Swisher, Stephen G., Zhou, Yihong, Behrens, Carmen, Raso, Maria Gabriela, Yu, Liping, Fang, Bingliang, Pataer, Apar, Wistuba, Ignacio I., He, Yong, Correa, Arlene M., Roth, Jack A.   +11 more
core   +1 more source

Differential effects of SUMO1 and SUMO3 on PKR activation and stability

, 2018
Double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is a serine/threonine kinase that exerts its own phosphorylation and the phosphorylation of the α subunit of the protein synthesis initiation factor eIF-2α.
Laurent Dianoux, Ghizlane Maarifi, Mohamed Ali Maroui, Mounira K. Chelbi-Alix, Faten El Asmi   +4 more
core   +1 more source

A new spot for PKR [PDF]

Nature Chemical Biology, 2018
openaire   +2 more sources

Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells

Journal of Inflammation Research, 2019
Youde Jiang, Jena J SteinleDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USAPurpose: Inflammation has been strongly associated with retinal damage in diseases such as diabetic ...
Jiang Y, Steinle JJ
doaj  

Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA

Disease Models & Mechanisms
Samuel B. Burnett, Allison M. Culver, Tricia A. Simon, Taylor Rowson, Kenneth Frederick, Kristina Palmer, Stephen A. Murray, Shannon W. Davis, Rekha C. Patel   +8 more
doaj   +1 more source

The role of interferon-stimulated long non-coding RNA PKR-IT1 in the regulation of Zika virus and dengue virus replication and antiviral response. [PDF]

Microbiol Spectr
Wang Y, Fu A, Chen L, Shi Y, Chen Q, Wang F, Huang Q, Liu S.   +7 more
europepmc   +1 more source

Adequacy of Clinical Information in Knee Radiography Requests With Reference to the Pittsburgh Knee Rule: A Single-Centre Clinical Audit. [PDF]

Cureus
Shrestha P, Park JY.
europepmc   +1 more source

Regulation of endogenous dsRNA: strategies for self-tolerance. [PDF]

Open Biol
Heraud-Farlow J, Chan YP, Davidson S, Walkley C.   +3 more
europepmc   +1 more source

Akabane virus reprograms the PKR‑eIF2α‑SGs/PBs axis to fine-tune cap-snatching efficiency. [PDF]

Virulence
Liu Z, Chen D, Qin J, Wang J, Wang D, Ruan W, Xu S.   +6 more
europepmc   +1 more source