Results 111 to 120 of about 30,951 (226)

Down- and upregulation of PKR gene expression by PKR siRNA or by a PKR-expression plasmid, respectively, in liver cancer cell lines, Huh 7.5.1, JFH1 and H77s.

, 2013
Cells were transfected with either PKR siRNA or control siRNA, then PKR mRNA was quantified by real-time RT-PCR; PKR was knocked down (A). Cells were transfected with PKR-expression plasmid (pPKR) or control plasmid (pOS8), then subjected to real-time RT-
Bunzo Matsuura (429489), Morikazu Onji (429490), Yoshio Ikeda (260838), Raymond T. Chung (214536), Yoichi Hiasa (156596), Masanori Abe (421879), Takao Watanabe (429486), Yoshio Tokumoto (429487), Masashi Hirooka (429488)   +8 more
core   +1 more source

Default Effect in ESG Investment: When a Recommendation Goes a Long Way

Business Strategy and the Environment, Volume 35, Issue 7, Page 9155-9175, November 2026.
ABSTRACT Individual investors display a positive attitude toward ESG investments but typically fail to act upon it. We report results from a preregistered online experiment testing a default option on 1050 US investors examining the mechanisms driving the effectiveness of default options in promoting ESG investments.
Sai Sravanthi Ramadugula, R. Prasantha Kumar, Luc Meunier   +2 more
wiley   +1 more source

PKR pening kepala kerenah Pas [PDF]

, 2017
Selepas tulus tahaluf siyasi dengan PKR, Pas seolah-olah sengaja mahu menimbulkan provokasi dan menguji kesabaran pemimpin parti itu. Semalam, Naib Presiden Pas, Datuk Mohd Amar Nik Abdullah kembali memanaskan keadaan apabila secara tegas menyebut ...
Tarmizi, Azmi
core   +1 more source

PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis

Scientific Reports
RNA-dependent protein kinase (PKR) may have a positive regulatory role in controlling tumor growth and progression in hepatocellular carcinoma (HCC). However, the downstream substrates and the molecular mechanism of PKR in the growth and progression of ...
Yusuke Okujima, Takao Watanabe, Takeshi Ito, Yasumichi Inoue, Yutaka Kasai, Yusuke Imai, Yoshiko Nakamura, Mitsuhito Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Ryosuke Kawakami, Takashi Saitou, Takeshi Imamura, Yoshinori Murakami, Yoichi Hiasa   +16 more
doaj   +1 more source

PKR; a sentinel kinase for cellular stress [PDF]

Oncogene, 1999
The double stranded RNA (dsRNA)-activated protein kinase PKR is a ubiquitously expressed serine/threonine protein kinase that is induced by interferon and activated by dsRNA, cytokine, growth factor and stress signals. It is essential for cells to respond adequately to different stresses including growth factor deprivation, products of the inflammatory
openaire   +2 more sources

Therapeutic and Prophylactic Agents for Viral Diseases: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 11, November 2026.
This review summarizes current therapeutic and prophylactic strategies for global viral diseases, including vaccines, PrEP, direct‐acting antivirals, and emerging modalities such as CRISPR and siRNA. It highlights their clinical impact, ongoing challenges, and future priorities toward broader protection, improved delivery, and more effective antiviral ...
Sawar Khan, Ayesha Nisar, Xiaoxu Li, Hao Yu, Abdul Qadeer, Sardar Azhar Mehmood, Imane Lamraoui, Sijie Liu, Lipeng Zhu, Xu Deng, Bo Kong, Kejun Zhong, Zanxian Xia   +12 more
wiley   +1 more source

Antimicrobial Activity and In Silico ADME Properties of Tyrosol and Their Derivatives Compounds

ChemistrySelect, Volume 11, Issue 41, 3 November 2026.
In the present study, tyrosol derivatives were obtained with the aim of improving their antimicrobial activity. Derivative 2 exhibited good antimicrobial activity, with an MIC of 3.9 µg/mL. Derivative 3, meanwhile, showed moderate activity and is novel in the literature. ABSTRACT According to the World Health Organization (WHO), bacterial resistance is
Kathia Raquel Murillo Padilla, Rayanne Priscila Vieira da Conceição, José Edson de Sousa Siqueira, Luana Cardoso de Oliveira, Mayra Suelen da Silva Pinheiro, Patrícia Santana Barbosa Marinho, Andrey Moacir do Rosario Marinho   +6 more
wiley   +1 more source

The Vaccinia Virus E3L Gene Product Interacts with both the Regulatory and the Substrate Binding Regions of PKR: Implications for PKR Autoregulation

, 1998
The vaccinia virus E3L gene product, pE3, is a dsRNA binding protein that prevents activation of the interferon-induced, dsRNA-activated protein kinase, PKR. Activation of PKR, which results in phosphorylation of the translation initiation factor, eIF2α,
Moonan, F., Romashko, A., Jagus, R., Joshi, B., Barber, G.N., Sharp, T.V, Sharp, T.V., Romashko, A, Jagus, R, Barber, G.N, Moonan, F, Joshi, B   +11 more
core   +1 more source

Cardiovirus-Mediated PKR inhibition results from nucleocytoplasmic trafficking disruption.

PLoS Pathogens
Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), known as PKR, is a key antiviral kinase activated by double-stranded RNA (dsRNA) typically produced during viral replication.
Romane Milcamps, Belén Lizcano-Perret, Fanny Wavreil, Marielle Lebrun, Chiara Aloise, Didier Vertommen, Gaëtan Herinckx, Frank J M van Kuppeveld, Catherine Sadzot, Thomas Michiels   +9 more
doaj   +1 more source

Empirical Parameterizations of ULF Power and Drift Orbit Averaged Radial Diffusion Coefficients From Ground Magnetometers for Different MLT

Earth and Space Science, Volume 13, Issue 11, November 2026.
Abstract Radial diffusion, driven by ultra‐low frequency (ULF) waves, is an important process for the transport of electrons in the outer radiation belt. Ground magnetometers give us constant observations of such ULF waves but their usefulness is limited by the models used to transform ground measurements into their progenitor fields in space.
S. Dimitrakoudis, G. Balasis, A. Z. Boutsi, I. A. Daglis, C. Papadimitriou, C. Katsavrias, M. Georgiou, J. Lichtenberger   +7 more
wiley   +1 more source