Results 91 to 100 of about 30,951 (226)
Activated PKR directly associates with the N-terminus of RHA.
, 2013 (A) An autoradiograph of 35S-labeled PKR, pulled down with GSTRHA fusion proteins and GST alone. Amino acid end points for the RHA construct are indicated over each lane.
Anthony J. Sadler (374383) +4 more
core +1 more source
Paediatric and Perinatal Epidemiology, EarlyView.ABSTRACT Background Although migrants are recognised as heterogeneous, research often emphasises origin over receiving‐context experiences. Objectives We investigated maternal risk factors and perinatal outcomes by duration of residence in Australia, stratified by region of birth.
Natalie Holowko +5 more
wiley +1 more source
A dominant-negative PKR mutant increases Env.EGFP reporter expression.
, 2013 HeLa cells were analysed by flow cytometry 48 h post-transfection with the pNL-140.EGFP reporter and plasmids expressing either wild-type PKR, an N-terminal PKR mutant (PKR-N) or plasmid backbone alone (pcDNA3). Values represent the relative fluorescence
Marina R. Alexander (354145) +5 more
core +1 more source
Frontiers in Genetics, 2019 A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation ...
Raymond Kaempfer +5 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
HBx-siRNA promoted the expression of PKR and the activation of PKR signaling pathway.
, 2013 (A) Real-time PCR was used to analyze the mRNA expression of PKR after HBx-siRNAs treatment for 24 h. The mRNA level in each sample was expressed as fold change compared with RNA level in LF-treated cells.
Cai Zhang (163340) +3 more
core +1 more source
Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation
The Journal of Physiology, EarlyView.Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min +2 more
wiley +1 more source
HeLa WT and HeLa PKR KO cells were transiently transfected with a pCAGGS-IFI27-HA plasmid (IFI27 O.E.) or an empty pCAGGS plasmid (empty). 24 hours post-transfection, protein extracts were obtained by lysis and the protein levels of total PKR and β-actin
López-García, Darío +3 more
core +1 more source
The kinase activity of PKR represses inflammasome activity [PDF]
, 2016 The protein kinase R (PKR) functions in the antiviral response by controlling protein translation and inflammatory cell signaling pathways. We generated a transgenic, knock-in mouse in which the endogenous PKR is expressed with a point mutation that ...
Die Wang +13 more
core +1 more source
The International Journal of Health Planning and Management, Volume 41, Issue 6, Page 1174-1188, December 2026.ABSTRACT Pakistan has hosted Afghan refugees for more than four decades, in one of the world's most protracted displacements of people. Afghan refugees receive health services through United Nations High Commissioner for Refugees (UNHCR) and non‐governmental organisation (NGO) supported programmes alongside public sector facilities at every tier.
Zahid Ali Memon +4 more
wiley +1 more source