Results 51 to 60 of about 30,951 (226)
Diagnostic Pathology, 2012 Background Protein kinase RNA (PKR-regulated) is a double-stranded RNA activated protein kinase whose expression is induced by interferon. The role of PKR in cell growth regulation is controversial, with some studies supporting a tumour suppressor ...
Mohamed Amal A +2 more
doaj +1 more source
A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists. [PDF]
PLoS Pathogens, 2016 During millions of years of coevolution with their hosts, cytomegaloviruses (CMVs) have succeeded in adapting to overcome host-specific immune defenses, including the protein kinase R (PKR) pathway.
Kathryn S Carpentier +3 more
doaj +1 more source
Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly
Advanced Science, EarlyView.LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang +6 more
wiley +1 more source
TRIM21 represses PKR activation by targeting on PP1α.
, 2023 (A) HEK293T cells pre-infected with lentivirus-sh-vector (sh-vector) or lentivirus-sh-TRIM21 (sh-TRIM21) for 24 h were transfected with p3xFlag-CMV-PKR for additional 48 h, then infected with VSV (MOI = 0.2) for 6 h.
Jingjing Wang (140791) +16 more
core +1 more source
Deficient PKR in RAX/PKR Association Ameliorates Ethanol-Induced Neurotoxicity in the Developing Cerebellum [PDF]
The Cerebellum, 2015 Ethanol-induced neuronal loss is closely related to the pathogenesis of fetal alcohol spectrum disorders. The cerebellum is one of the brain areas that are most sensitive to ethanol. The mechanism underlying ethanol neurotoxicity remains unclear. Our previous in vitro studies have shown that the double-stranded RNA (dsRNA)-activated protein kinase (PKR)
Hui, Li +9 more
openaire +2 more sources
pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain
Brain, Behavior, & Immunity - Health, 2023 We recently demonstrated that prothrombin kringle-2 (pKr-2) derived from blood-brain barrier (BBB) disruption could induce hippocampal neurodegeneration and object recognition impairment through neurotoxic inflammatory responses in the five familial ...
Sehwan Kim +5 more
doaj +1 more source
Advanced Science, EarlyView.Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti +11 more
wiley +1 more source
, 2013 (A) A silver-stained, SDS-PAGE gel of electrophoretically separated proteins immunoprecipitated with mouse monoclonal anti-PKR (IP-PKR) from pkr-null MEFs transformed with a human pkr construct either expressed (+) or silenced (−) and stimulated with pIC
Anthony J. Sadler (374383) +4 more
core +1 more source
Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death
Neurobiology of Disease, 2018 Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy comprise a group of neurodegenerative diseases termed synucleinopathies. Synucleinopathie are, characterized by presence of inclusion bodies in degenerating brain cells which ...
Lasse Reimer +10 more
doaj +1 more source
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source