Results 21 to 30 of about 30,951 (226)

Activation of PKR by RNA misfolding: HDV ribozyme dimers activate PKR [PDF]

RNA, 2012
Protein Kinase R (PKR), the double-stranded RNA (dsRNA)-activated protein kinase, plays important roles in innate immunity. Previous studies have shown that PKR is activated by long stretches of dsRNA, RNA pseudoknots, and certain single-stranded RNAs; however, regulation of PKR by RNAs with globular tertiary structure has not been reported.
Laurie A, Heinicke, Philip C, Bevilacqua
openaire   +2 more sources

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]

, 2009
The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R., Kohl, A., Rodriguez-Andres, J., Kohl, Alain, Breakwell, L, Barry, G, Fazakerley, J.K., Breakwell, Lucy, Attarzadeh-Yazdi, G., Kohl, A, Barry, Gerald, Fazakerley, John K, Attarzadeh-Yazdi, G, Fazakerley, JK, Fragkoudis, R, Barry, G., Attarzadeh-Yazdi, Ghassem, Rodriguez-Andres, J, Breakwell, L., Rodriguez-Andres, Julio, Fragkoudis, Rennos   +20 more
core   +1 more source

Aktivitas Pengajaran PKR A2 [PDF]

, 2023
Pengajaran PKR ...
Hadna Suryantari, PGSD, FKIP
core   +1 more source

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A., Boyd, A, Fazakerley, John K., Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, J. K. Fazakerley, Elliott, Richard M, Boyd, Amanda, H. Streitenfeld, Elliott, R.M., Streitenfeld, H., A. Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J K, Fazakerley, J.K., F. Weber, R. M. Elliott, Bridgen, A, Elliott, Richard Michael, Bridgen, Anne, A. Boyd   +25 more
core   +1 more source

Aktivitas Pengajaran PKR A5 [PDF]

, 2023
Pengajaran PKR ...
Hadna Suryantari, PGSD, FKIP
core   +1 more source

PKR stirs up inflammasomes [PDF]

Cell Research, 2012
Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; active caspase-1, in turn, matures the pro-inflammatory IL-1β family cytokines by cleaving their pro-forms into the biologically active cytokines.
Stunden, H James, Latz, Eicke
openaire   +3 more sources

Aktivitas Pengajaran PKR A3 [PDF]

, 2023
Pengajaran PKR ...
Hadna Suryantari, PGSD, FKIP
core   +1 more source

PKR-Dependent Inflammatory Signals [PDF]

Science Signaling, 2012
The RNA-dependent protein kinase activates the inflammasome to promote inflammation.
Rui, Kang, Daolin, Tang
openaire   +2 more sources

PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells

OncoImmunology, 2018
The immunogenic cell death (ICD) process represents a novel therapeutic approach to treat tumours, in which cytotoxic compounds promote both cancer cell death and the emission of damage-associated molecular patterns (DAMPs) from dying cells, to activate ...
Paola Giglio, Mara Gagliardi, Nicola Tumino, Fernanda Antunes, Soraya Smaili, Diego Cotella, Claudio Santoro, Roberta Bernardini, Maurizio Mattei, Mauro Piacentini, Marco Corazzari   +10 more
doaj   +1 more source

Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)

mBio, 2019
Protein kinase R (PKR) plays a major role in activating host immunity during infection by sensing double-stranded RNA (dsRNA) produced by viruses. Once activated by dsRNA, PKR phosphorylates the translation factor eukaryotic initiation factor 2α (eIF2α),
Danielle E. Goodman, Carla D. Pretto, Tomas A. Krepostman, Kelly E. Carnahan, Katherine R. Spindler   +4 more
doaj   +1 more source