Results 11 to 20 of about 30,951 (226)
Inhibition of PKR by Viruses [PDF]
Frontiers in Microbiology, 2021 Cells respond to viral infections through sensors that detect non-self-molecules, and through effectors, which can have direct antiviral activities or adapt cell physiology to limit viral infection and propagation.
Teresa Cesaro, Thomas Michiels
doaj +5 more sources
Virology, 1997 The RNA-dependent protein kinase (PKR) is implicated in the antiviral and antiproliferative actions of interferon. Mutant forms of human PKR display a transdominant behavior when expressed in transfected cells. The potential for the human PKR protein to physically interact with the mouse PKR homolog has therefore been examined.
Rende-Fournier, Rosanna +3 more
openaire +3 more sources
An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation
Cell ReportsSummary: Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon induction is prevented, die soon after birth.
Ketty Sinigaglia +14 more
doaj +3 more sources
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.
PLoS Pathogens, 2016 Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection.
Alissa M Pham +5 more
doaj +2 more sources
PKR modulates abnormal brain signaling in experimental obesity. [PDF]
PLoS ONE, 2018 Metabolic disorders including obesity and type 2 diabetes are known to be associated with chronic inflammation and are obvious risk factors for Alzheimer's disease. Recent evidences concerning obesity and diabetes suggest that the metabolic inflammasome (
Mariko Taga +10 more
doaj +3 more sources
MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation. [PDF]
Adv Sci (Weinh)This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Li J +8 more
europepmc +2 more sources
Contribution of dsRBD2 to PKR Activation [PDF]
ACS Omega, 2021 Protein kinase R (PKR) is a key pattern recognition receptor of the innate immune pathway. PKR is activated by double-stranded RNA (dsRNA) that is often produced during viral genome replication and transcription. PKR contains two tandem double-stranded RNA binding domains at the N-terminus, dsRBD1 and dsRBD2, and a C-terminal kinase domain.
Stephen Hesler +3 more
openaire +3 more sources
PKR: A Kinase to Remember [PDF]
Frontiers in Molecular Neuroscience, 2019 Aging is a major risk factor for many diseases including metabolic syndrome, cancer, inflammation, and neurodegeneration. Identifying mechanistic common denominators underlying the impact of aging is essential for our fundamental understanding of age-related diseases and the possibility to propose new ways to fight them.
Shunit Gal-Ben-Ari +4 more
openaire +3 more sources
Advances in Cytosolic dsRNA Sensing of Viral Infections. [PDF]
Immunol Cell BiolActivation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Maceratessi S, Sampaio NG.
europepmc +2 more sources
Aktivitas Pengajaran PKR A4 [PDF]
, 2023 Pengajaran PKR ...
Hadna Suryantari, PGSD, FKIP
core +1 more source