Results 51 to 60 of about 18,219,543 (287)
Journal of Pharmacological Sciences, 2016 Intrathecal (i.t.) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) induces long-lasting nociceptive behaviors for more than 60 min in mice, while the involvement of PACAP type1 receptor (PAC1-R) has not been clarified yet ...
Tetsuya Ohnou +8 more
doaj +1 more source
TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes
Neurobiology of Disease, 2019 TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS).
Thomas J. LaRocca +3 more
doaj +1 more source
Protein kinase R-like endoplasmic reticulum kinase pathway and diabetic kidney disease
Linchuang shenzangbing zazhi, 2020 Endoplasmic reticulum stress is closely related to the occurrence and development of diabetic kidney disease.As an important signaling pathway induced by endoplasmic reticulum stress,protein kinase R-like endoplasmic reticulum kinase(PERK)pathway can ...
庞欣欣 +5 more
doaj
Salicylates Trigger Protein Synthesis Inhibition in a Protein Kinase R-like Endoplasmic Reticulum Kinase-dependent Manner [PDF]
Journal of Biological Chemistry, 2007 The non-steroidal anti-inflammatory drug aspirin and its metabolite, sodium salicylate, have profound effects on cellular protein synthesis and cell physiology. However, the underlying mechanism by which they cause these responses remains unclear.
Aristóbolo M, Silva +4 more
openaire +2 more sources
Frontiers in Neuroscience, 2017 Necrotic cell death is a hallmark feature of ischemic stroke and it may facilitate inflammation by releasing intracellular components after cell-membrane rupture.
Mei Yang +8 more
doaj +1 more source
Journal of Pharmacopuncture, 2019 DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
doaj +1 more source
Hepatic stellate cell proliferation: A potential role of protein kinase R [PDF]
Hepatology, 2011 n ...
Ceccarelli, Sara +3 more
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Journal of Pharmacological Sciences, 2010 The mechanism for sustained Ca2+ influx activated by G protein–coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a ...
Tsunaki Higa +7 more
doaj +1 more source
Binding and Nuclear Relocalization of Protein Kinase R by Human Cytomegalovirus TRS1 [PDF]
Journal of Virology, 2006 ABSTRACT The human cytomegalovirus (HCMV) TRS1 and IRS1 genes block the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2α) and the consequent shutoff of cellular protein synthesis that occur during infection with vaccinia virus (VV) deleted of the double-stranded RNA binding protein gene E3L (VVΔE3L).
Morgan, Hakki +3 more
openaire +3 more sources