Results 51 to 60 of about 23,156,384 (284)

Protein kinase R-like endoplasmic reticulum kinase pathway and diabetic kidney disease

Linchuang shenzangbing zazhi, 2020
Endoplasmic reticulum stress is closely related to the occurrence and development of diabetic kidney disease.As an important signaling pathway induced by endoplasmic reticulum stress,protein kinase R-like endoplasmic reticulum kinase(PERK)pathway can ...
庞欣欣, 彭紫凝, 邢玉凤, 张雅歌, 石秀杰, 韩佳瑞   +5 more
doaj  

Salicylates Trigger Protein Synthesis Inhibition in a Protein Kinase R-like Endoplasmic Reticulum Kinase-dependent Manner [PDF]

Journal of Biological Chemistry, 2007
The non-steroidal anti-inflammatory drug aspirin and its metabolite, sodium salicylate, have profound effects on cellular protein synthesis and cell physiology. However, the underlying mechanism by which they cause these responses remains unclear.
Aristóbolo M, Silva, Die, Wang, Anton A, Komar, Beatriz A, Castilho, Bryan R G, Williams   +4 more
openaire   +2 more sources

Activation of adenosine 3‘,5‘-monophosphate-dependent protein kinase and its relationship to cyclic AMP and lipolysis in hamster adipose tissue.

Journal of Lipid Research, 1980
The interrelationships among cAMP-dependent protein kinase activity, lipolysis, and cellular concentrations of cAMP were investigated in hamster epididymal adipose tissue.
R J Schimmel, C A Buhlinger, R Serio
doaj   +1 more source

Lipoxin A4-induced heme oxygenase-1 protects cardiomyocytes against hypoxia/reoxygenation injury via p38 MAPK activation and Nrf2/ARE complex. [PDF]

PLoS ONE, 2013
To investigate whether lipoxin A4 (LXA4) increases expression of heme oxygenase-1(HO-1) in cardiomyocytes, whether LXA4-induced HO-1 protects cardiomyocytes against hypoxia/reoxygenation (H/R) injury, and what are the mechanisms involved in the LXA4 ...
Xiao-Qing Chen, Sheng-Hua Wu, Yu Zhou, Yan-Rong Tang   +3 more
doaj   +1 more source

Binding and Nuclear Relocalization of Protein Kinase R by Human Cytomegalovirus TRS1 [PDF]

Journal of Virology, 2006
ABSTRACT The human cytomegalovirus (HCMV) TRS1 and IRS1 genes block the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2α) and the consequent shutoff of cellular protein synthesis that occur during infection with vaccinia virus (VV) deleted of the double-stranded RNA binding protein gene E3L (VVΔE3L).
Morgan, Hakki, Emily E, Marshall, Katherine L, De Niro, Adam P, Geballe   +3 more
openaire   +3 more sources

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro

Frontiers in Neuroscience, 2017
Necrotic cell death is a hallmark feature of ischemic stroke and it may facilitate inflammation by releasing intracellular components after cell-membrane rupture.
Mei Yang, Yongjiu Lv, Xiaocui Tian, Jie Lou, Ruidi An, Qian Zhang, Minghang Li, Lu Xu, Zhi Dong   +8 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Requirement for protein kinase R in interleukin-1α-stimulated effects in cartilage [PDF]

Biochemical Pharmacology, 2007
Interleukin-1 (IL-1) has pleiotropic effects in cartilage. The interferon-induced, double stranded RNA-activated protein kinase PKR that phosphorylates eukaryotic initiation factor 2 (eIF2) alpha has been implicated in cytokine effects in chondrocytes.
Christine L, Tam, Maria, Hofbauer, Christine A, Towle   +2 more
openaire   +2 more sources

Control of PKA stability and signalling by RING ligase praja2 [PDF]

, 2010
Ligand-mediated activation of G-Protein Coupled Receptors (GPCRs) mobilises compartmentalised pulses of second messengers like cAMP. The main cellular effector of cAMP is Protein Kinase A (PKA) which is assembled as inactive holoenzyme consisting of two ...
Lignitto, Luca
core   +1 more source

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Journal of Pharmacopuncture, 2019
DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
doaj   +1 more source