Results 21 to 30 of about 9,912 (196)

Oncolytic Poxviruses [PDF]

open access: yesAnnual Review of Virology, 2014
Current standard treatments of cancer can prolong survival of many cancer patients but usually do not effectively cure the disease. Oncolytic virotherapy is an emerging therapeutic for the treatment of cancer that exploits replication-competent viruses to selectively infect and destroy cancerous cells while sparing normal cells and tissues.
Winnie M, Chan, Grant, McFadden
openaire   +2 more sources

Enhancing the Protective Immune Response to Administration of a LIVP-GFP Live Attenuated Vaccinia Virus to Mice

open access: yesPathogens, 2021
Following the WHO announcement of smallpox eradication, discontinuation of smallpox vaccination with vaccinia virus (VACV) was recommended. However, interest in VACV was soon renewed due to the opportunity of genetic engineering of the viral genome by ...
Sergei N. Shchelkunov   +4 more
doaj   +1 more source

BAFfled by Poxviruses? [PDF]

open access: yesCell Host & Microbe, 2007
Successful viruses engage in a dynamic interplay with their hosts, where both utilize diverse strategies to impose their supremacy. In this issue of Cell Host & Microbe, Wiebe and Traktman describe a novel interaction between vaccinia virus and mammalian cells.
Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida Southwest Archer Road, P.O. Box 100332, Gainesville, FL 32610, USA ( host institution )   +2 more
openaire   +3 more sources

Fludarabine, a Potential DNA-Dependent RNA Polymerase Inhibitor, as a Prospective Drug against Monkeypox Virus: A Computational Approach

open access: yesPharmaceuticals, 2022
Monkeypox is a zoonotic contagious disease that has recently re-emerged in different countries worldwide. Due to the lack of an effective treatment that eliminates the virus, there is an urgent need to find effective drugs to stop the spread of the multi-
Hisham N. Altayb
doaj   +1 more source

Monkeypox and other zoonotic poxviruses

open access: yes, 2022
Poxviruses have caused the most important diseases for humanity for a long time. An important triumph was achieved with the eradication of smallpox, defined by the World Health Organization in 1979.
Ahmet Kürşat AZKUR   +5 more
core   +1 more source

Comparative analysis of existing platforms for the development of vaccines against dangerous and extremely dangerous viral infections with pandemic potential

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2021
The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko   +3 more
doaj   +1 more source

Poxvirus Interactions with the Host Ubiquitin System

open access: yesPathogens, 2021
The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions. With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in ...
Sian Lant, Carlos Maluquer de Motes
doaj   +1 more source

In Silico Repurposed Drugs against Monkeypox Virus

open access: yesMolecules, 2022
Monkeypox is an emerging epidemic of concern. The disease is caused by the monkeypox virus and an increasing global incidence with a 2022 outbreak that has spread to Europe amid the COVID-19 pandemic. The new outbreak is associated with novel, previously
Hilbert Yuen In Lam   +2 more
doaj   +1 more source

Zoonotic poxviruses

open access: yesVeterinary Microbiology, 2010
(Uploaded by Plazi for the Bat Literature Project) Poxviruses compromise a group of long known important pathogens including some zoonotic members affecting lifestock animals and humans. While whole genome sequence analysis started to shed light into the molecular mechanisms underlying host cell infection, viral replication as well as virulence, our ...
Essbauer, Sandra   +2 more
openaire   +3 more sources

Una nueva alerta mundial en salud causada por la viruela del simio

open access: yesInterdisciplinary Journal of Epidemiology and Public Health, 2022
Introducción: La viruela del simio es una zoonosis de etiología viral causada por virus de la viruela del simio. Es una enfermedad endémica en los países africanos.
Richar Jose Gomez de la Rosa   +1 more
doaj   +1 more source

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