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Current standard treatments of cancer can prolong survival of many cancer patients but usually do not effectively cure the disease. Oncolytic virotherapy is an emerging therapeutic for the treatment of cancer that exploits replication-competent viruses to selectively infect and destroy cancerous cells while sparing normal cells and tissues.
Winnie M, Chan, Grant, McFadden
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Following the WHO announcement of smallpox eradication, discontinuation of smallpox vaccination with vaccinia virus (VACV) was recommended. However, interest in VACV was soon renewed due to the opportunity of genetic engineering of the viral genome by ...
Sergei N. Shchelkunov +4 more
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Successful viruses engage in a dynamic interplay with their hosts, where both utilize diverse strategies to impose their supremacy. In this issue of Cell Host & Microbe, Wiebe and Traktman describe a novel interaction between vaccinia virus and mammalian cells.
Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida Southwest Archer Road, P.O. Box 100332, Gainesville, FL 32610, USA ( host institution ) +2 more
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Monkeypox is a zoonotic contagious disease that has recently re-emerged in different countries worldwide. Due to the lack of an effective treatment that eliminates the virus, there is an urgent need to find effective drugs to stop the spread of the multi-
Hisham N. Altayb
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Monkeypox and other zoonotic poxviruses
Poxviruses have caused the most important diseases for humanity for a long time. An important triumph was achieved with the eradication of smallpox, defined by the World Health Organization in 1979.
Ahmet Kürşat AZKUR +5 more
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The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko +3 more
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Poxvirus Interactions with the Host Ubiquitin System
The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions. With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in ...
Sian Lant, Carlos Maluquer de Motes
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In Silico Repurposed Drugs against Monkeypox Virus
Monkeypox is an emerging epidemic of concern. The disease is caused by the monkeypox virus and an increasing global incidence with a 2022 outbreak that has spread to Europe amid the COVID-19 pandemic. The new outbreak is associated with novel, previously
Hilbert Yuen In Lam +2 more
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(Uploaded by Plazi for the Bat Literature Project) Poxviruses compromise a group of long known important pathogens including some zoonotic members affecting lifestock animals and humans. While whole genome sequence analysis started to shed light into the molecular mechanisms underlying host cell infection, viral replication as well as virulence, our ...
Essbauer, Sandra +2 more
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Una nueva alerta mundial en salud causada por la viruela del simio
Introducción: La viruela del simio es una zoonosis de etiología viral causada por virus de la viruela del simio. Es una enfermedad endémica en los países africanos.
Richar Jose Gomez de la Rosa +1 more
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