Results 71 to 80 of about 10,656 (197)

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, Volume 13, Issue 56, 9 October 2026.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Summary of SAMD9/L restriction factors in human and mice and their antagonism by different poxviruses.

, 2018
The K1 and C7-like proteins encoded by the representative mammalian poxviruses are shown on the right. The two amino acid variations in SPPV-063 is shown as two additional lines.
Akiko Nagamachi (517904), Hiroaki Honda (517912), Chuanping Si (175385), Yan Xiang (50965), Xiangzhi Meng (310468), Bo Yan (57900), Lu-Zhe Sun (218962), Fushun Zhang (158697)   +7 more
core   +1 more source

Taming Mre11–Rad50 at Telomeres: Convergent Strategies for Chromosome‐End Protection Across Evolution

BioEssays, Volume 48, Issue 10, October 2026.
All telomeres must be protected from DNA repair enzymes. This review explores how, from bacteriophages to mammals, unrelated telomere proteins have converged on the same recurring strategies: inhibiting the Mre11–Rad50 nuclease directly or physically shielding DNA ends. ABSTRACT Telomere biology is often framed as a uniquely eukaryotic problem, yet the
Florian Roisné‐Hamelin, Stephan Gruber   +1 more
wiley   +1 more source

The Lord of the Rings: Cysteine bonds crosslink the tail of siphovirus

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Long, non‐contractile tails composed of helical hexameric protein repeats that assemble into continuous tubular structures characterize siphoviruses. The siphovirus tail tube protein gp39 contains two cysteine residues per monomer. Cryo‐electron microscopy revealed that these cysteines are oriented toward the interface between the rings, which
Simona Povilonienė, Giedrius Sasnauskas, Giedrė Tamulaitienė, Greta Labutytė, Martynas Talaikis, Algirdas Mikšys, Aurelija Zajančkauskaitė, Lidija Truncaitė, Rolandas Meškys, Vida Časaitė   +9 more
wiley   +1 more source

Poxviruses Aren't StuPYD [PDF]

Immunity, 2005
Pathogens utilize many strategies to dampen the host inflammatory response. In this issue of Immunity, a report by Johnston and colleagues reveals a poxvirus strategy that inhibits the inflammasome, arresting secretion of interleukin-1-related cytokines, thus silencing key alarms that mobilize host defenses.
Benedict, Chris A., Ware, Carl F.
openaire   +2 more sources

A Review of Nonsteroidal Anti‐Inflammatory Drugs for Food‐Producing Animals With a Focus on Potential Applications for Farmed Finfish

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT In finfish aquaculture, there are several inflammatory diseases impacting productivity and animal welfare, however there are limited options available to veterinarians to treat inflammation and pain in fish. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used in terrestrial animals raised for human consumption to treat a range of ...
Chloe J. English, Christine Huynh, William Roy, James W. Wynne, Hamish Rodger   +4 more
wiley   +1 more source

The evolutionary biology of poxviruses [PDF]

Infection, Genetics and Evolution, 2010
The poxviruses (family Poxviridae) are a family of double-stranded viruses including several species that infect humans and their domestic animals, most notably Variola virus (VARV), the causative agent of smallpox. The evolutionary biology of these viruses poses numerous questions, for which we have only partial answers at present.
Austin L, Hughes, Stephanie, Irausquin, Robert, Friedman   +2 more
openaire   +2 more sources

Characterization of DNA-binding activity of Zα domains from poxviruses and the importance of the β-wing regions in converting B-DNA to Z-DNA [PDF]

, 2007
The E3L gene is essential for pathogenesis in vaccinia virus. The E3L gene product consists of an N-terminal Zα domain and a C-terminal double-stranded RNA (dsRNA) binding domain; the left-handed Z-DNA-binding activity of the Zα domain of E3L is required
Rich, Alexander, Kim, Kyeong Kyu, Kim, Yang-Gyun, Ha, Sung Chul, Lowenhaupt, Ky, Quyen, Dong Van   +5 more
core   +1 more source

Insult to Injury: Population Impacts of Sublethal Entanglement and Vessel Strikes of Common Bottlenose Dolphins (Tursiops truncatus) in Barataria Basin, Louisiana, 2011–2023

Marine Mammal Science, Volume 42, Issue 4, October 2026.
ABSTRACT Human interactions, specifically fishery entanglements (FI) and vessel strikes (VI), threaten marine mammals, including the Barataria Bay Estuarine System (BBE) Stock of common bottlenose dolphins (Tursiops truncatus). We reviewed whole‐body photographs to estimate the prevalence of sublethal entanglement and vessel strike scars for 227 ...
Eric S. Zolman, Todd Speakman, Jeanine Morey, Leslie Hart, Cynthia R. Smith, Wayne McFee, Lori Schwacke, Ryan Takeshita   +7 more
wiley   +1 more source

Nck- and N-WASP-dependent actin-based motility is conserved in divergent vertebrate poxviruses

, 2009
SummaryVaccinia virus enhances its cell-to-cell spread by stimulating actin polymerization via Src- and Abl-mediated phosphorylation of the highly conserved orthopoxvirus protein A36.
Way, Michael, Dodding, Mark P, Dodding, M P   +2 more
core   +1 more source