Results 91 to 100 of about 9,912 (196)
From actually toxic to highly specific – novel drugs against poxviruses
, 2007 The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral
Schnierle Barbara +3 more
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PathogensSince smallpox vaccination was discontinued in 1980, there has been a resurgence of poxvirus infections, particularly the monkeypox virus. Without a global recommendation to use the smallpox vaccine, the population is not immune, posing a severe threat ...
Karolina Gregorczyk-Zboroch +12 more
doaj +1 more source
, 2008 Vaccinia virus (VACV) C7L is a host-range gene that regulates cellular tropism of VACV. Distantly related C7L homologues are encoded by nearly all mammalian poxviruses, but whether they are host-range genes functioning similar to VACV C7L has not been ...
Xiang, Yan, Chao, Jie, Meng, Xiangzhi
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A System Based-Approach to Examine Cytokine Response in Poxvirus-Infected Macrophages
Viruses, 2018 The poxviruses are large, linear, double-stranded DNA viruses about 130 to 230 kbp, that have an animal origin and evolved to infect a wide host range.
Pui-San Wong +5 more
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Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus [PDF]
, 1998 Recently, myxoma virus was shown to encode an additional member of the serpin superfamily. The viral gene, called serp2, was cloned, and the Serp2 protein was shown to specifically bind to interleukin-1beta (IL-1beta)-converting enzyme (ICE), thus ...
Messud-Petit, Frédérique +6 more
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Nck- and N-WASP-Dependent Actin-Based Motility Is Conserved in Divergent Vertebrate Poxviruses
, 2009 SummaryVaccinia virus enhances its cell-to-cell spread by stimulating actin polymerization via Src- and Abl-mediated phosphorylation of the highly conserved orthopoxvirus protein A36.
Dodding, Mark P. +3 more
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Poxviruses that cause human disease
, 2010 RESUMEN: Los poxvirus se dividen en dos subfamilias: la Cordopoxvirinae con ocho géneros que infectan tanto a mamíferos como a aves, y la Entomopoxvirinae con tres géneros que sólo afectan a los insectos.
Correa Londoño, Luis Alfonso +1 more
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NK Cells and Poxvirus infection
Frontiers in Immunology, 2013 In recent years our understanding of the role of NK cells in the response to viral infection has grown rapidly. Not only do we realize viruses have many immune evasion strategies to escape NK cell responses, but that stimulation of NK cell subsets ...
Deborah N. Burshtyn
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Poxviruses Taking a Ride on Actin: New Users of Known Hardware
, 2009 Vaccinia virus uses A36 to recruit the actin polymerization effectors Nck and N-WASP to drive actin tail formation. Now, Dodding and Way identify functional orthologs of A36 in other vertebrate poxviruses that harbor varying numbers of Nck-binding sites ...
Rottner, Klemens, Stradal, Theresia E.B.
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, 2015 The phylogenetic tree was constructed by MEGA 5 software and the confidence levels were calculated using bootstrapping (2000 replicates). Only bootstrap values greater than 50 are shown.
Nick Davison (408480) +8 more
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