Results 111 to 120 of about 2,497,817 (373)

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]

, 2015
Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A., Goto, G.H., Henry, E., Ogi, H., Sugimoto, K., Zencir, Sevil   +5 more
core   +1 more source

Binding and Nuclear Relocalization of Protein Kinase R by Human Cytomegalovirus TRS1 [PDF]

Journal of Virology, 2006
ABSTRACT The human cytomegalovirus (HCMV) TRS1 and IRS1 genes block the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2α) and the consequent shutoff of cellular protein synthesis that occur during infection with vaccinia virus (VV) deleted of the double-stranded RNA binding protein gene E3L (VVΔE3L).
Morgan, Hakki, Emily E, Marshall, Katherine L, De Niro, Adam P, Geballe   +3 more
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain [PDF]

, 1983
A calcium and calmodulin-dependent protein kinase has been purified from rat brain. It was monitored during the purification by its ability to phosphorylate the synaptic vesicle-associated protein, synapsin I.
Bennett, Mark K., Erondu, Ngozi E., Kennedy, Mary B.   +2 more
core  

Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway [PDF]

, 2006
We report a multiwavelength (X-ray, ultraviolet/optical/infrared, radio) analysis of the relativistic tidal disruption event candidate Sw J2058+05 from 3 months to 3 yr post-discovery in order to study its properties and compare its behavior with that of
Bower, Geoffrey C., Brown, Gregory C., Cenko, S. Bradley, Dolan, Stephen, Filippenko, Alexei V., Fruchter, Andrew S., Greiner, Jochen, Horesh, Assaf, Hounsell, Rebekah A., Levan, Andrew J., O'Brien, Paul T., Page, Kim L., Pasham, Dheeraj R., Rau, Arne, Tanvir, Nial R., Wiersema, Klaas   +15 more
core   +2 more sources

The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia–reperfusion injury by suppressing RIPK1-mediated necroptosis and apoptosis

Acta Pharmaceutica Sinica B
Receptor-interacting protein kinase 1 (RIPK1) plays an essential role in regulating the necroptosis and apoptosis in cerebral ischemia-reperfusion (I/R) injury.
Tengfei Liu, Gan Huang, Xin Guo, Qiuran Ji, Lu Yu, Runzhe Zong, Yiquan Li, Xiaomeng Song, Qingyi Fu, Qidi Xue, Yi Zheng, Fanshuo Zeng, Ru Sun, Lin Chen, Chengjiang Gao, Huiqing Liu   +15 more
doaj   +1 more source

Requirement for protein kinase R in interleukin-1α-stimulated effects in cartilage [PDF]

Biochemical Pharmacology, 2007
Interleukin-1 (IL-1) has pleiotropic effects in cartilage. The interferon-induced, double stranded RNA-activated protein kinase PKR that phosphorylates eukaryotic initiation factor 2 (eIF2) alpha has been implicated in cytokine effects in chondrocytes.
Christine L, Tam, Maria, Hofbauer, Christine A, Towle   +2 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice [PDF]

, 2005
Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six
Buxton, RS, Colston, MJ, Curry, JM, Gohil, K, Hunt, DM, Rickman, L, Smerdon, SJ, Strom, M, Whalan, R   +8 more
core   +2 more sources

Physcomitrella patens Has Kinase-LRR R Gene Homologs and Interacting Proteins

PLoS ONE, 2014
Plant disease resistance gene (R gene)-like sequences were screened from the Physcomitrella patens genome. We found 603 kinase-like, 475 Nucleotide Binding Site (NBS)-like and 8594 Leucine Rich Repeat (LRR)-like sequences by homology searching using the respective domains of PpC24 (Accession No. BAD38895), which is a candidate kinase-NBS-LRR (kinase-NL)
Tanigaki, Yusuke, Ito, Kenji, Obuchi, Yoshiyuki, Kosaka, Akiko, Yamato, Katsuyuki T., Okanami, Masahiro, Lehtonen, Mikko T., Valkonen, Jari P. T., Akita, Motomu   +8 more
openaire   +5 more sources