Results 221 to 230 of about 2,497,817 (373)

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

Journal of Clinical Investigation, 1989
P. Craven, F. Derubertis
semanticscholar   +1 more source

Hepatic stellate cell proliferation: A potential role of protein kinase R [PDF]

Hepatology, 2011
Sara, Ceccarelli, Nadia, Panera, Anna, Alisi, Valerio, Nobili   +3 more
openaire   +2 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of <i>Leishmania donovani</i> in Macrophages. [PDF]

Front Immunol, 2022
Dias BT, Goundry A, Vivarini AC, Costa TFR, Mottram JC, Lopes UG, Lima APCA.   +6 more
europepmc   +1 more source

Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade

Molecular and Cellular Biology, 2000
M. Lasa, K. Mahtani, A. Finch, G. Brewer, J. Saklatvala, A. Clark   +5 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Coronavirus Endoribonuclease Ensures Efficient Viral Replication and Prevents Protein Kinase R Activation. [PDF]

J Virol, 2021
Zhao J, Sun L, Zhao Y, Feng D, Cheng J, Zhang G.   +5 more
europepmc   +1 more source

Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

, 1996
Christian Herrmann, Gudrun Horn, Marcel Spaargaren, Alfred Wittinghofer   +3 more
openalex   +1 more source

Somatic mutations of the protein kinase gene family in human lung cancer.

Cancer Research, 2005
Helen R Davies, C. Hunter, Raffaella Smith, P. Stephens, C. Greenman, G. Bignell, J. Teague, A. Butler, S. Edkins, C. Stevens, A. Parker, S. O’Meara, T. Avis, S. Barthorpe, L. Brackenbury, G. Buck, J. Clements, J. Cole, E. Dicks, Ken Edwards, S. Forbes, Matthew Gorton, K. Gray, Kelly Halliday, R. Harrison, K. Hills, Jonathon Hinton, David Jones, Vivian Kosmidou, Ross Laman, R. Lugg, A. Menzies, J. Perry, R. Petty, K. Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne R Stephens, Calli Tofts, J. Varian, A. Webb, S. West, S. Widaa, Andrew D. Yates, F. Brasseur, C. Cooper, A. Flanagan, A. Green, M. Knowles, S. Leung, Leendert H. J. Looijenga, B. Malkowicz, M. Pierotti, B. Teh, S. Yuen, S. Lakhani, D. Easton, B. Weber, P. Goldstraw, A. Nicholson, R. Wooster, Michael R. Stratton, P. Futreal   +63 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source