Results 161 to 170 of about 6,714,405 (407)
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
Microbiology and Molecular Reviews, 2011 Marie Cargnello, Philippe P Roux
semanticscholar +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
The sites of phosphorylation of rabbit cardiac troponin I by adenosine 3′:5′-cyclic monophosphate-dependent protein kinase. Effect of interaction with troponin C [PDF]
, 1977 Arthur J.G. Moir, S V Perry
openalex +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Protein kinase activity in commercially available crystalline yeast alcohol dehydrogenase [PDF]
, 1973 Bruce E. Kemp +2 more
openalex +1 more source
Genistein, a specific inhibitor of tyrosine-specific protein kinases.
Journal of Biological Chemistry, 1987 Tetsu AkiyamaSO +7 more
semanticscholar +1 more source
Fyn-Mediated Regulation of Protein Kinase A [PDF]
, 2017 Protein kinases are enzymes important for signal transduction in the regulation of cellular processes. The cAMP-dependent protein kinase A (PKA) has been previously reported to regulate the activity of the Src family kinase Fyn, an event important for ...
Barritt, Sam
core +1 more source