Results 181 to 190 of about 3,902,190 (305)

Recent medicinal chemistry efforts of targeting protein kinases for treating neurological conditions of Parkinson's and Alzheimer's diseases. [PDF]

RSC Adv
Kaur R, Lang DK, Sood A, Singh TG, Chandrasekaran B, Al-Sha'er MA.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Structure-conditioned self-supervised learning of residue interaction constraints in protein kinases for variant interpretation. [PDF]

Bioinformatics
Fadaei S, Krebs FS, Zoete V.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Identification and Validation of an Inhibitor of the Protein Kinases PIM and DYRK. [PDF]

J Med Chem
Bencze G, Venkataramani P, Elkayam E, Rivera KD, Garg A, Szabadakai I, Orfi L, Joshua-Tor L, Pappin DJ, Tonks NK.   +9 more
europepmc   +1 more source

Discriminating activating, deactivating and resistance variants in protein kinases. [PDF]

Genome Med
Singh G, Schmenger T, Gonzalez-Sanchez JC, Kutkina A, Bremec N, Diwan GD, Mozas P, López C, Siebert R, Sotillo R, Russell RB.   +10 more
europepmc   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Functional analysis of <i>Candida albicans</i> protein kinases identifies Crk1 as a modulator of epithelial cell damage. [PDF]

mBio
Möslinger A, Weiner A, Schäuble S, Ramírez-Zavala B, Jablonowski N, Cseresnyés Z, Schille TB, Figge MT, Panagiotou G, Morschhäuser J, Kasper L, Gresnigt MS, Allert S, Hube B.   +13 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Decoding the allosteric grammar of protein kinases: A dual-stream framework integrating protein language models and energy landscape frustration analysis. [PDF]

Protein Sci
Gatlin W, Ludwick M, Turano L, Foley B, Riedlová K, Škrhák V, Novotný M, Hoksza D, Verkhivker GM.   +8 more
europepmc   +1 more source