Results 191 to 200 of about 875,741 (363)

Hormonal Regulation of Cyclic‐AMP‐Dependent Protein Kinase of Rat Diaphragm by Epinephrine and Insulin [PDF]

, 1973
Otto Walaas, E. Walaas, Ole Grønnerød
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Crustacean Protein Kinases A and C: Bioinformatic Characterization in Decapods and Other Non-Model Organisms. [PDF]

Int J Mol Sci
Head TB, Pérez-Moreno JL, Antizzo LE, Durica DS, Mykles DL.   +4 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The protein kinases family in fungi: adaptability, virulence and conservation between species. [PDF]

Front Microbiol
La Santrer E, Assunção CB, de Camargo TMN, Rodrigues I, Campolina SS, de Aguiar EL, de Souza Rodrigues T, Caligiorne RB.   +7 more
europepmc   +1 more source

Modulation of Soluble Ovarian Adenosine 3′,5′-Monophosphate-Dependent Protein Kinase Activity during Prepubertal Development in the Rat. II. Evaluation of the Catalytic Subunit Inhibitor Activity1 [PDF]

, 1989
Mary Hunzicker-Dunn, Nancy Lorenzini‡, Richard E. Cutler, RICHARD C. EKSTROM, Evelyn T. Maizels   +4 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Role of Protein Kinases in the Suppressive Phenotype of Myeloid-Derived Suppressor Cells. [PDF]

Int J Mol Sci
Kali A, Abdolla N, Perfilyeva YV, Ostapchuk YO, Tleulieva R.   +4 more
europepmc   +1 more source

Molecular Dynamics Simulations of the Catalytic Subunit of Protein Kinase a Reveal New Insight into the Catalytic Process [PDF]

, 2014
Tian Jianhui, Loukas Petridis, William T. Heller   +2 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source