Results 201 to 210 of about 856,952 (362)

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

A Critical Look at the Crystal Structures of cAMP-Dependent Protein Kinases. [PDF]

Kinases Phosphatases
Wlodawer A, Rubach P, Dauter Z, Dec W, Minor W, Brzezinski D, Jaskolski M.   +6 more
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Dr. Kinase: predicting the drug-resistance hotspots of protein kinases. [PDF]

Nucleic Acids Res
Lin S, Tu C, Hu R, Wang H, Dong Z, Luo H, Kuang L, Wang T, Wang L, Zhao Z, Li Z, Xu H.   +11 more
europepmc   +1 more source

Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis.

, 1979
Patricia A. Rae, N S Gutmann, Jennivine Tsao, Bernard P. Schimmer   +3 more
openalex   +1 more source

Mechanism of Activation of Protein Kinase I from Rabbit Skeletal Muscle. Mapping of the cAMP Site by Spin-Labeled Cyclic Nucleotides [PDF]

, 1978
Jürgen Hoppe, Erwin Rieke, Karl Wagner
openalex   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

The protein kinases family in fungi: adaptability, virulence and conservation between species. [PDF]

Front Microbiol
La Santrer E, Assunção CB, de Camargo TMN, Rodrigues I, Campolina SS, de Aguiar EL, de Souza Rodrigues T, Caligiorne RB.   +7 more
europepmc   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

The Role of Protein Kinases in the Suppressive Phenotype of Myeloid-Derived Suppressor Cells. [PDF]

Int J Mol Sci
Kali A, Abdolla N, Perfilyeva YV, Ostapchuk YO, Tleulieva R.   +4 more
europepmc   +1 more source