Results 21 to 30 of about 6,714,405 (407)

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases [PDF]

Journal of Biological Chemistry, 2005
The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK kinases (AMPKKs).
Anthony R. Means, Jeanne M. Franzone, Rebecca L. Hurley, Bruce E. Kemp, Lee A. Witters, Kristin A. Anderson   +5 more
openaire   +3 more sources

A framework for classification of prokaryotic protein kinases. [PDF]

PLoS ONE, 2010
BACKGROUND: Overwhelming majority of the Serine/Threonine protein kinases identified by gleaning archaeal and eubacterial genomes could not be classified into any of the well known Hanks and Hunter subfamilies of protein kinases.
Nidhi Tyagi, Krishanpal Anamika, Narayanaswamy Srinivasan   +2 more
doaj   +1 more source

DYRK protein kinases [PDF]

Current Biology, 2015
Soppa and Becker introduce the DYRK family of dual specificity protein kinases and their diverse functions and associations with genetic diseases.
Ulf Soppa, Walter Becker
openaire   +3 more sources

A-kinase-anchoring proteins [PDF]

Journal of Cell Science, 2004
Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation ([Pawson and Nash, 2003][1]). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-
John D. Scott, Lorene K. Langeberg
openaire   +4 more sources

The Kinase Specificity of Protein Kinase Inhibitor Peptide [PDF]

Frontiers in Pharmacology, 2021
G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA), which integrates inputs from three major types of GPCRs.
Yao Chen, Yao Chen, Bernardo L. Sabatini
openaire   +5 more sources

Author Correction: YAP1/TAZ drives ependymoma-like tumour formation in mice

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Noreen Eder, Federico Roncaroli, Marie-Charlotte Domart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Jun-Hao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, Sila K. Ultanir   +14 more
doaj   +1 more source

Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling [PDF]

, 2011
Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling.
Abdi, Agarwal, Allen, Anamika, Behnke, Billker, Billker, Bishop, Blethrow, Bracchi-Ricard, Bradley, Brian M. Cooke, Butcher, Carruthers, Carvalho, Christian Doerig, Cooke, Cooke, Coppi, Dalpke, Daniel C. Lim, Dar, Doerig, Doerig, Doerig, Dorin, Dorin, Dorin, Droucheau, El Hajj, Fennell, Fentress, Gilbert, Green, Gueirard, Halbert, Hanks, Huse, Hutti, Ishino, Jensen, Jeroen P.J. Saeij, Kafsack, Kannan, Kato, Khaminets, Khan, Khan, Khan, Kieschnick, Kun, Kuo, Labesse, Ling, Lodoen, Lourido, Luder, Manning, Martens, Melzer, Nagamune, Nunes, Nunes, Ojo, Ong, Parsons, Peixoto, Pernas, Qiu, Reese, Reese, Reese, Reininger, Reininger, Reininger, Rosenberg, Rosowski, Saeij, Saeij, Scheibel, Schneider, Shiels, Sicard, Singh, Singh, Solyakov, Sopko, Steinfeldt, Sugi, Suss-Toby, Taylor, Taylor, Tewari, Vaid, van de Sand, Ward, Ward, Wernimont, Wernimont, Xu, Yamamoto, Yasukawa, Zeqiraj, Zeqiraj, Zhao, Zhao   +105 more
core   +2 more sources

YAP1/TAZ drives ependymoma-like tumour formation in mice

Nature Communications, 2020
YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.
Noreen Eder, Federico Roncaroli, Marie-Charlotte Domart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Jun-Hao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, Sila K. Ultanir   +14 more
doaj   +1 more source

Targeting protein kinases for anti-glioma treatment

Folia Neuropathologica, 2021
The genetic alterations related to many kinases are responsible for the formation of glial tumours. In addition it is the cell kinases that keep the cancerous signalling machinery in motion, thus enabling tumour cell growth, motility and invasion. Kinase
Emanuela Pucko, Robert Ostrowski
doaj   +1 more source

Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus [PDF]

, 2008
Background: Protein kinases are key enzymes that regulate a wide range of cellular processes, including cell-cycle progression, transcription, DNA replication and metabolic functions. These enzymes catalyse the transfer of phosphates to serine, threonine
Gasser, Robin B., Hu, Min, LaRonde-LeBlanc, Nicole, Sternberg, Paul W.   +3 more
core   +6 more sources