Results 41 to 50 of about 3,902,190 (305)

Identification of casein kinase 1, casein kinase 2, and cAMP-dependent protein kinase-like activities in Trypanosoma evansi

Memorias do Instituto Oswaldo Cruz, 2004
Trypanosoma evansi contains protein kinases capable of phosphorylating endogenous substrates with apparent molecular masses in the range between 20 and 205 kDa.
José Manuel Galán-Caridad, Maritza Calabokis, Graciela Uzcanga, Frank Aponte, José Bubis   +4 more
doaj   +1 more source

Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis

Molecules, 2022
Schistosomiasis is a neglected tropical disease affecting more than 200 million people worldwide. Chemotherapy relies on one single drug, praziquantel, which is safe but ineffective at killing larval stages of this parasite.
Bernardo Pereira Moreira, Michael H. W. Weber, Simone Haeberlein, Annika S. Mokosch, Bernhard Spengler, Christoph G. Grevelding, Franco H. Falcone   +6 more
doaj   +1 more source

The Arabidopsis CDPK-SnRK superfamily of protein kinases [PDF]

, 2003
The CDPK-SnRK superfamily consists of seven types of serine-threonine protein kinases: calcium-dependent protein kinase (CDPKs), CDPK-related kinases (CRKs), phosphoenolpyruvate carboxylase kinases (PPCKs), PEP carboxylase kinase-related kinases (PEPRKs),
Halford, N, Luan, S, Hrabak, EM, Nimmo, H. G., Halford, N. G., Chan, C. W. M., Harper, J. F., Kudla, J, Gribskov, M., Sussman, MR, Walker-Simmons, K., Choi, J. H., Chan, CWM, Harmon, AC, Thomas, M., Sussman, M. R., Walker-Simmons, K, Gribskov, M, Nimmo, HG, Choi, JH, Zhu, JK, Hrabak, E. M., Thomas, M, Kudla, J., Zhu, J-K., Harmon, A. C., Harper, JF, Luan, S.   +27 more
core   +1 more source

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]

Journal of Biological Chemistry, 2005
(R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S., Knockaert, M., Reinhardt, J., Lozach, O., Schmitt, S., Baratte, B., Koken, M., S. P., Coburn, Tang, L., Jiang, T., D. C., Liang, Galons, H., J. F., Dierick, L. A., Pinna, Meggio, F., Totzke, F., Schachtele, C., Lerman, A. S., Carnero, A., Wan, Y., Gray, N., Meijer, L.   +21 more
openaire   +5 more sources

Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]

, 2005
Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
core   +1 more source

Lipid activation of protein kinases

Journal of Lipid Research, 2009
Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase ...
Alexandra C. Newton
doaj   +1 more source

Exploring the chemotherapeutic potential of currently used kinase inhibitors: An update

Frontiers in Pharmacology, 2023
Protein kinases are enzymes that transfer phosphate to protein, resulting in the modification of the protein. The human genome encodes approximately 538 kinases.
Rajashri R. Naik, Ashok K. Shakya
doaj   +1 more source

The protein tyrosine kinases EpsB and PtkA differentially affect biofilm formation in Bacillus subtilis [PDF]

, 2014
The Gram-positive soil bacterium Bacillus subtilis is able to choose between motile and sessile lifestyles. The sessile way of life, also referred to as biofilm, depends on the formation of an extracellular polysaccharide matrix and some extracellular ...
Stanley-Wall, Nicola, Stuelkel, Joerg, Gunka, Katrin, Stülke, Jörg, Stanley-Wall, Nicola; id_orcid, Gerwig, Jan, Kiley, Taryn B.   +6 more
core   +1 more source

Unusual features and localization of the membrane kinome of Trypanosoma brucei.

PLoS ONE, 2021
In many eukaryotes, multiple protein kinases are situated in the plasma membrane where they respond to extracellular ligands. Ligand binding elicits a signal that is transmitted across the membrane, leading to activation of the cytosolic kinase domain ...
Bryan C Jensen, Pashmi Vaney, John Flaspohler, Isabelle Coppens, Marilyn Parsons   +4 more
doaj   +2 more sources

Protein Kinase C [PDF]

IUBMB Life, 2000
Phosphorylation is a universal language used by cells to relay information between and within cells. One family of kinases that plays a key role in transducing information is the protein kinase C family. Members of this family interpret information from signals that result in phospholipid hydrolysis; they communicate to substrates throughout the cell ...
openaire   +2 more sources