Results 41 to 50 of about 554,867 (317)
Molecular insights into the regulatory interactions of Dystrophia myotonica protein kinase [PDF]
, 2006 Dystrophia Myotonica Protein Kinase (DMPK) is the defining member of a family of complex, multidomain kinases of major biomedical relevance. These kinases are characterized by a highly conserved catalytic domain and a coiled-coil motif (CC) involved in ...
Garcia, Pilar
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Lipid activation of protein kinases
Journal of Lipid Research, 2009 Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase ...
Alexandra C. Newton
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KSP: an integrated method for predicting catalyzing kinases of phosphorylation sites in proteins
BMC Genomics, 2020 Background Protein phosphorylation by kinases plays crucial roles in various biological processes including signal transduction and tumorigenesis, thus a better understanding of protein phosphorylation events in cells is fundamental for studying protein ...
Hongli Ma, Guojun Li, Zhengchang Su
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Nek family of kinases in cell cycle, checkpoint control and cancer [PDF]
, 2011 Early studies in lower Eukaryotes have defined a role for the members of the NimA related kinase (Nek) family of protein kinases in cell cycle control. Expansion of the Nek family throughout evolution has been accompanied by their broader involvement in ...
Haider Nasir +11 more
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Unusual features and localization of the membrane kinome of Trypanosoma brucei.
PLoS ONE, 2021 In many eukaryotes, multiple protein kinases are situated in the plasma membrane where they respond to extracellular ligands. Ligand binding elicits a signal that is transmitted across the membrane, leading to activation of the cytosolic kinase domain ...
Bryan C Jensen +4 more
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Protein Kinases and Addiction [PDF]
Annals of the New York Academy of Sciences, 2008 Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug‐induced changes in synaptic plasticity due to alterations in cell signaling, gene transcription, and ...
Anna M, Lee, Robert O, Messing
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The kinomes of apicomplexan parasites [PDF]
, 2012 Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we
Gabaldón, Toni +9 more
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eLifeA study of two enzymes in the brain reveals new insights into how redox reactions regulate the activity of protein kinases.
Iván Plaza-Menacho
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Integrated Technology Platform Protein Kinases for Drug Development in Oncology
BioTechniques, 2002 Protein kinases are among the most promising targets for drug discovery and development, mostly in oncology but also in other fields such as inflammation, Alzheimer's, and infectious diseases.
Christoph Sachsenmaier +1 more
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Involvement of protein kinases associated signal transduction mechanisms in cardiac diseases
Exploration of Medicine, 2023 Protein kinases, a family of enzymes responsible for regulating various cellular processes, have been implicated in the development and progression of various heart diseases, making them attractive therapeutic targets.
Jaykrishan Prasad +2 more
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