Results 51 to 60 of about 3,902,190 (305)

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source

JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]

, 2006
MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core   +1 more source

Neuronal migration and protein kinases

Frontiers in Neuroscience, 2015
The formation of the six-layered structure of the mammalian cortex via the inside-out pattern of neuronal migration is fundamental to neocortical functions.
Toshio eOhshima
doaj   +1 more source

Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome

Biomolecules, 2022
Phosphorylation facilitates the regulation of all fundamental biological processes, which has triggered extensive research of protein kinases and their roles in human health and disease.
Aziz M. Rangwala, Victoria R. Mingione, George Georghiou, Markus A. Seeliger   +3 more
doaj   +1 more source

KSP: an integrated method for predicting catalyzing kinases of phosphorylation sites in proteins

BMC Genomics, 2020
Background Protein phosphorylation by kinases plays crucial roles in various biological processes including signal transduction and tumorigenesis, thus a better understanding of protein phosphorylation events in cells is fundamental for studying protein ...
Hongli Ma, Guojun Li, Zhengchang Su
doaj   +1 more source

Secreted protein kinases [PDF]

Trends in Biochemical Sciences, 2013
Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Vincent S. Tagliabracci, PINNA, LORENZO, Jack E. Dixon   +2 more
openaire   +3 more sources

The kinomes of apicomplexan parasites [PDF]

, 2012
Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we
Gabaldón, Toni, Doerig, Christian, Gabaldón, T., Barton, Geoffrey J.; id_orcid, Barton, G., Miranda-Saavedra, Diego, Miranda-Saavedra, D., Langsley, Gordon, Langsley, G., Doerig, C.   +9 more
core   +1 more source

Redox takes control

eLife
A study of two enzymes in the brain reveals new insights into how redox reactions regulate the activity of protein kinases.
Iván Plaza-Menacho
doaj   +1 more source

Integrated Technology Platform Protein Kinases for Drug Development in Oncology

BioTechniques, 2002
Protein kinases are among the most promising targets for drug discovery and development, mostly in oncology but also in other fields such as inflammation, Alzheimer's, and infectious diseases.
Christoph Sachsenmaier, Christoph Schäechtele   +1 more
doaj   +1 more source

Involvement of protein kinases associated signal transduction mechanisms in cardiac diseases

Exploration of Medicine, 2023
Protein kinases, a family of enzymes responsible for regulating various cellular processes, have been implicated in the development and progression of various heart diseases, making them attractive therapeutic targets.
Jaykrishan Prasad, Anureet K. Shah, Naranjan S. Dhalla   +2 more
doaj   +1 more source