Results 21 to 30 of about 554,867 (317)
Non-degradative Ubiquitination of Protein Kinases. [PDF]
PLoS Computational Biology, 2016 Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation. In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non ...
K Aurelia Ball +6 more
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The Tails of Protein Kinase A [PDF]
Molecular Pharmacology, 2022 Protein kinase A (PKA) is a holoenzyme consisting of a regulatory (R)-subunit dimer and two catalytic (C)-subunits. There are two major families of C-subunits, Cα and Cβ, and four functionally nonredundant R-subunits (RIα, RIβ, RIIα, RIIβ). In addition to binding to and being regulated by the R-subunits, the C-subunits are regulated by two tail regions
Susan S, Taylor +6 more
openaire +2 more sources
The Arabidopsis CDPK-SnRK superfamily of protein kinases [PDF]
, 2003 The CDPK-SnRK superfamily consists of seven types of serine-threonine protein kinases: calcium-dependent protein kinase (CDPKs), CDPK-related kinases (CRKs), phosphoenolpyruvate carboxylase kinases (PPCKs), PEP carboxylase kinase-related kinases (PEPRKs),
Halford, N +27 more
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Frontiers in Immunology, 2016 Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections.
Peter Epeh Kima, Naixin eZhang
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Subcellular partitioning of protein kinase activity revealed by functional kinome profiling
Scientific Reports, 2022 Protein kinases and their substrates form signaling networks partitioned across subcellular compartments to facilitate critical biological processes. While the subcellular roles of many individual kinases have been elucidated, a comprehensive assessment ...
Lauren Wegman-Points +6 more
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Targeting protein kinases for anti-glioma treatment
Folia Neuropathologica, 2021 The genetic alterations related to many kinases are responsible for the formation of glial tumours. In addition it is the cell kinases that keep the cancerous signalling machinery in motion, thus enabling tumour cell growth, motility and invasion. Kinase
Emanuela Pucko, Robert Ostrowski
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Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. [PDF]
, 2009 The human kinome containing 478 eukaryotic protein kinases has over 100 uncharacterized kinases with unknown substrates and biological functions. The Ser/Thr kinase 35 (STK35, Clik1) is a member of the NKF 4 (New Kinase Family 4) in the kinome with ...
Pankaj Goyal +11 more
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Multi-PK antibodies: Powerful analytical tools to explore the protein kinase world
Biochemistry and Biophysics Reports, 2017 Diverse biological events are regulated through protein phosphorylation mediated by protein kinases. Some of these protein kinases are known to be involved in the pathogenesis of various diseases.
Yasunori Sugiyama, Isamu Kameshita
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Frontiers in Cell and Developmental Biology, 2022 Peroxisomes are eukaryotic specific organelles that perform diverse metabolic functions including fatty acid β-oxidation, reactive species metabolism, photorespiration, and responses to stress. However, the potential regulation of these functions by post-
Amr Kataya +8 more
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Memorias do Instituto Oswaldo Cruz, 2004 Trypanosoma evansi contains protein kinases capable of phosphorylating endogenous substrates with apparent molecular masses in the range between 20 and 205 kDa.
José Manuel Galán-Caridad +4 more
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