Protein Kinase A in Cancer [PDF]
Cancers, 2011 In the past, many chromosomal and genetic alterations have been examined as possible causes of cancer. However, some tumors do not display a clear molecular and/or genetic signature. Therefore, other cellular processes may be involved in carcinogenesis.
CARETTA A, MUCIGNAT, CARLA
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Metabolic Kinases Moonlighting as Protein Kinases [PDF]
Trends in Biochemical Sciences, 2018 Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and ...
Zhimin, Lu, Tony, Hunter
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Author Correction: YAP1/TAZ drives ependymoma-like tumour formation in mice
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Noreen Eder +14 more
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SnRK2 Protein Kinases-Key Regulators of Plant Response to Abiotic Stresses [PDF]
, 2011 The SnRK2 family members are plant-specific serine/threonine kinases involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development.
Wawer, Izabela +9 more
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YAP1/TAZ drives ependymoma-like tumour formation in mice
Nature Communications, 2020 YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.
Noreen Eder +14 more
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A-kinase-interacting protein localizes protein kinase A in the nucleus [PDF]
Proceedings of the National Academy of Sciences, 2005 The genetic variability and covalent modifications associated with the amino terminus of the protein kinase A (PKA) catalytic (C) subunit suggest that it may contribute to protein–protein interactions and/or localization. By using a yeast two-hybrid screen, we identified a PKA-interacting protein (AKIP1) that binds to the amino terminus (residues 1–39)
Mira, Sastri +3 more
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Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development [PDF]
, 2011 NDR kinases are highly conserved from yeast to man. Loss-of-function models of Ndr homologs in yeast and fly demonstrate essential functions of the respective kinases.
Schmitz-Rohmer, Debora
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Protein kinases as antituberculosis targets: The case of thymidylate kinases
Frontiers in Bioscience-Landmark, 2020 This review is a concise summary of studies involving the design, synthesis and characterization of potential inhibitors against thymidylate kinase of Mycobacterium tuberculosis.
Sudarkodi Sukumar +2 more
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Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A
IUBMB Life, 2023 AbstractAlthough Fischer's extraordinary career came to focus mostly on the protein phosphatases, after his co‐discovery of Phosphorylase Kinase with Ed Krebs he was clearly intrigued not only by cAMP‐dependent protein kinase (PKA), but also by the heat‐stable, high‐affinity protein kinase inhibitor (PKI).
Susan S. Taylor +3 more
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Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]
, 2012 Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
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