Results 41 to 50 of about 845,655 (386)

Reciprocal regulation of PKA and rac signaling [PDF]

, 2013
Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml, Baillie, Bhola, Birukova, Cook, Cuevas, Daaka, Delcourt, Dewire, Dorsam, Dumaz, E. Stefan, Eblen, G. S. Baillie, Gerits, Gloerich, Hafner, Hoffmann, Howe, Jaffe, K. R. Liedl, Kinderman, King, Kraynov, Kumar, Ligr, Malbon, Manser, Molli, Nika, Pierce, R. G. Huber, Sahai, Sch  fer, Scott, Smith, Stefan, Stork, T. Valovka, Taylor, Thaker, V. A. Bachmann, Wang, Wennerberg, Wong, Zenke, Zhang, Zhao   +47 more
core   +1 more source

Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis

Molecules, 2022
Schistosomiasis is a neglected tropical disease affecting more than 200 million people worldwide. Chemotherapy relies on one single drug, praziquantel, which is safe but ineffective at killing larval stages of this parasite.
Bernardo Pereira Moreira, Michael H. W. Weber, Simone Haeberlein, Annika S. Mokosch, Bernhard Spengler, Christoph G. Grevelding, Franco H. Falcone   +6 more
doaj   +1 more source

Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts [PDF]

, 2015
Aims. Protein kinases are potential therapeutic targets for heart failure, but most studies of cardiac protein kinases derive from other systems, an approach that fails to account for specific kinases expressed in the heart and the contractile ...
Alessi, Angela Clerk, Bruce G. Allen, Clerk, George Vaniotis, Lompré, Michelle A. Hardyman, Peter H. Sugden, Sally A. Osborne, Sam J. Leonard, Stephen J. Fuller, Stokoe   +11 more
core   +1 more source

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]

Journal of Biological Chemistry, 2005
(R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S., Knockaert, M., Reinhardt, J., Lozach, O., Schmitt, S., Baratte, B., Koken, M., S. P., Coburn, Tang, L., Jiang, T., D. C., Liang, Galons, H., J. F., Dierick, L. A., Pinna, Meggio, F., Totzke, F., Schachtele, C., Lerman, A. S., Carnero, A., Wan, Y., Gray, N., Meijer, L.   +21 more
openaire   +7 more sources

Signals fly when kinases meet Rho-of-plants (ROP) small G-proteins [PDF]

, 2015
Rho-type small GTP-binding plant proteins function as two-state molecular switches in cellular signalling. There is accumulating evidence that Rho-of-plants (ROP) signalling is positively controlled by plant receptor kinases, through the ROP guanine ...
Fehér, Attila, Lajkó Dézi, Bianka
core   +1 more source

Neuronal migration and protein kinases

Frontiers in Neuroscience, 2015
The formation of the six-layered structure of the mammalian cortex via the inside-out pattern of neuronal migration is fundamental to neocortical functions.
Toshio eOhshima
doaj   +1 more source

Exploring the chemotherapeutic potential of currently used kinase inhibitors: An update

Frontiers in Pharmacology, 2023
Protein kinases are enzymes that transfer phosphate to protein, resulting in the modification of the protein. The human genome encodes approximately 538 kinases.
Rajashri R. Naik, Ashok K. Shakya
doaj   +1 more source

Advance in Reversible Covalent Kinase Inhibitors [PDF]

arXiv, 2021
Reversible covalent kinase inhibitors (RCKIs) are a class of novel kinase inhibitors attracting increasing attention because they simultaneously show the selectivity of covalent kinase inhibitors, yet avoid permanent protein-modification-induced adverse effects.
arxiv  

MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. [PDF]

, 2020
Abiotic stresses, including drought and salinity, trigger a complex osmotic-stress and abscisic acid (ABA) signal transduction network. The core ABA signalling components are snf1-related protein kinase2s (SnRK2s), which are activated by ABA-triggered ...
Ceciliato, Paulo HO, Dubeaux, Guillaume, Ge, Chennan, Hauser, Felix, Hsu, Po-Kai, Munemasa, Shintaro, Schroeder, Julian I, Takahashi, Yohei, Zhang, Jingbo, Zhang, Li, Zhao, Yunde   +10 more
core  

Protein kinase B [PDF]

Current Biology, 2000
Vanhaesebroeck B, Alessi, DR: The PI3K-PDK1 connection: more than just a road to PKB.Biochem J 2000, 346:561-576.Scheid MP, Woodgett JR: Protein kinases: six degrees of separation?Curr Biol 2000, 10:R191-R194.Coffer P, Jin J, Woodgett JR: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.Biochem J 1998 ...
openaire   +3 more sources