Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types [PDF]
, 2017 In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many ...
Bose, Ron, Kumar, Runjun D
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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase [PDF]
Cell Metabolism, 2005 The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both the cellular and whole-body levels. Two upstream kinases have been reported to activate AMPK in cell-free assays, i.e., the tumor suppressor LKB1 and calmodulin-dependent protein kinase kinase. However, evidence that this is physiologically relevant currently only
Hawley, Simon A. +7 more
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KSP: an integrated method for predicting catalyzing kinases of phosphorylation sites in proteins
BMC Genomics, 2020 Background Protein phosphorylation by kinases plays crucial roles in various biological processes including signal transduction and tumorigenesis, thus a better understanding of protein phosphorylation events in cells is fundamental for studying protein ...
Hongli Ma, Guojun Li, Zhengchang Su
doaj +1 more source
Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome
Biomolecules, 2022 Phosphorylation facilitates the regulation of all fundamental biological processes, which has triggered extensive research of protein kinases and their roles in human health and disease.
Aziz M. Rangwala +3 more
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Positional information readout in $Ca^{2+}$ signaling
, 2019 Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target ...
Kruse, Karsten +2 more
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An evolutionary perspective on the kinome of malaria parasites [PDF]
, 2012 Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin +6 more
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Domain-mediated interactions for protein subfamily identification [PDF]
, 2020 Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain.
Han S.K. +5 more
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eLifeA study of two enzymes in the brain reveals new insights into how redox reactions regulate the activity of protein kinases.
Iván Plaza-Menacho
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Integrated Technology Platform Protein Kinases for Drug Development in Oncology
BioTechniques, 2002 Protein kinases are among the most promising targets for drug discovery and development, mostly in oncology but also in other fields such as inflammation, Alzheimer's, and infectious diseases.
Christoph Sachsenmaier +1 more
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Purification and Characterization of a Chloroplast Outer-Envelope-Bound, ATP-Dependent Protein Kinase [PDF]
, 1988 An ATP-dependent protein kinase was partially purified from isolated outer envelope membranes of pea (Pisum sativum L., Progress No. 9) chloroplasts. The purified kinase had a molecular weight of 70 kilodaltons, as determined by sodium dodecyl sulfate ...
Soll, Jürgen
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