Results 51 to 60 of about 6,819,213 (411)
Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments [PDF]
, 2018 Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane sensor histidine kinase and a ...
Janczarek, Monika +3 more
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Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]
Journal of Biological Chemistry, 2005 (R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S. +21 more
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Exploring the chemotherapeutic potential of currently used kinase inhibitors: An update
Frontiers in Pharmacology, 2023 Protein kinases are enzymes that transfer phosphate to protein, resulting in the modification of the protein. The human genome encodes approximately 538 kinases.
Rajashri R. Naik, Ashok K. Shakya
doaj +1 more source
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*)
Journal of Biological Chemistry, 1995 AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed ofJun and Fos subunits. The composition, the level and the activity of AP1 complexes are regulated in response to extracellular stimuli. An important role
M. Karin
semanticscholar +1 more source
IUBMB Life, 2000 Phosphorylation is a universal language used by cells to relay information between and within cells. One family of kinases that plays a key role in transducing information is the protein kinase C family. Members of this family interpret information from signals that result in phospholipid hydrolysis; they communicate to substrates throughout the cell ...
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Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome
Biomolecules, 2022 Phosphorylation facilitates the regulation of all fundamental biological processes, which has triggered extensive research of protein kinases and their roles in human health and disease.
Aziz M. Rangwala +3 more
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The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]
, 2008 The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda +61 more
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Lipid activation of protein kinases
Journal of Lipid Research, 2009 Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase ...
Alexandra C. Newton
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KSP: an integrated method for predicting catalyzing kinases of phosphorylation sites in proteins
BMC Genomics, 2020 Background Protein phosphorylation by kinases plays crucial roles in various biological processes including signal transduction and tumorigenesis, thus a better understanding of protein phosphorylation events in cells is fundamental for studying protein ...
Hongli Ma, Guojun Li, Zhengchang Su
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Secreted protein kinases [PDF]
Trends in Biochemical Sciences, 2013 Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Vincent S. Tagliabracci +2 more
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