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The Chemistry of Protein Oxidation in Food
Angewandte Chemie - International Edition, 2019AbstractOxidation is one of the deterioration reactions of proteins in food, the importance of which is comparable to others such as Maillard, lipation, or protein‐phenol reactions. While research on protein oxidation has led to a precise understanding of the processes and consequences in physiological systems, knowledge about the specific effects of ...
Michael Hellwig
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Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants
Archives of Biochemistry and Biophysics, 2014Human defensive peroxidases, including lactoperoxidase (LPO) and myeloperoxidase (MPO), are capable of catalyzing the oxidation of halides (X(-)) by H2O2 to give hypohalous acids (HOX) for the purpose of cellular defense. Substrate selectivity depends upon the relative abundance of the halides, but the pseudo-halide thiocyanate (SCN(-)) is a major ...
Vincent, Bonifay +5 more
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Protein oxidation in plant mitochondria detected as oxidized tryptophan
Free Radical Biology and Medicine, 2006The formation of N-formylkynurenine by dioxygenation of tryptophan was detected in peptides from rice leaf and potato tuber mitochondria. Proteins in matrix and membrane fractions were separated by two-dimensional gel electrophoresis and identified using a Q-TOF mass spectrometer. N-Formylkynurenine was detected in 29 peptides representing 17 different
Møller, Ian Max, Kristensen, Brian K.
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Immunohistochemical Detection of Protein Oxidation
2003The oxidative modification of proteins by reactive oxygen species (ROS) and other reactive compounds is associated with a number of disease and pathophysiological processes as well as aging (1). Under physiological conditions, almost all oxidative modifications of proteins are resulting in an increase of carbonylated proteins.
FRANK J, POMPELLA, ALFONSO, BIESALSKI HK
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Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress
Free Radical Biology and Medicine, 2012After oxidative stress, proteins that are oxidatively modified are degraded by the 20S proteasome. However, several studies have documented an enhanced ubiquitination of yet unknown proteins. Because ubiquitination is a prerequisite for degradation by the 26S proteasome in an ATP-dependent manner this raises the question whether these proteins are also
Kästle, Marc +3 more
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Analysis of Oxidative Modification of Proteins
Current Protocols in Protein Science, 2000AbstractProtein oxidation has been implicated in a variety of degenerative diseases as well as in the aging process. This unit describes techniques for the quantification of various protein oxidation products, including protein carbonyls, loss of protein thiol groups, dityrosine and nitrotyrosine, and isoaspartate formation.
L J, Yan, R S, Sohal
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Aging and Proteolysis of Oxidized Proteins
Archives of Biochemistry and Biophysics, 1994The main objective of this study was to investigate the possible cause(s) of the age-related augmentation of oxidatively damaged proteins in animal tissues. The hypothesis that activity of alkaline proteases, involved in the proteolysis of oxidized proteins, declines during aging was tested in the adult male housefly and further explored in the rat ...
S, Agarwal, R S, Sohal
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Oxidative protein damage and the proteasome
Amino Acids, 2010Protein damage, caused by radicals, is involved in many diseases and in the aging process. Therefore, it is crucial to understand how protein damage can be limited, repaired or removed. To degrade damaged proteins, several intracellular proteolytic systems exist.
S, Grimm, A, Höhn, T, Grune
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Quantification of protein modification by oxidants
Free Radical Biology and Medicine, 2009Proteins are major targets for oxidative damage due to their abundance and rapid rates of reaction with a wide range of radicals and excited state species, such as singlet oxygen. Exposure of proteins to these oxidants results in loss of the parent amino acid residue, formation of unstable intermediates, and the generation of stable products.
Clare L, Hawkins +2 more
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Aging and protein oxidative damage
Mechanisms of Ageing and Development, 1994The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase, the cytosolic enzymes that are particularly susceptible to oxidative damage.
S, Agarwal, R S, Sohal
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