Results 221 to 230 of about 573,078 (335)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A. [PDF]

Cell Rep
Shen C, Lu W, Merugu SB, Bharti A, Afify SM, Schnitkey L, Wynn DT, Yang F, Rohwetter TM, Nayak A, Bunnag N, Cywiak C, Tang HY, Harris BT, Albanese C, Ihemelandu C, Cobb MH, Kettenbach A, Lee E, Ahmed Y, Robbins DJ.   +20 more
europepmc   +1 more source

Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence. [PDF]

Aging Cell, 2023
Xing J, Chen K, Gao S, Pousse M, Ying Y, Wang B, Chen L, Wang C, Wang L, Hu W, Lu Y, Gilson E, Ye J.   +12 more
europepmc   +1 more source

Protein Phosphatase 2A Inhibitor LB-100 [PDF]

, 2020
openaire   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Protein Phosphatase 2A Promotes CD8⁺ T Cell Effector Function through the Augmentation of CD28 Costimulation. [PDF]

Research (Wash D C)
Zhu K, Rohila D, Zhao Y, Shytikov D, Wu L, Zhao F, Hu S, Xu Q, Jin X, Lu L.   +9 more
europepmc   +1 more source

Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA

, 2023
Brewer A, Sathe G, Pflug BE, Macartney TJ, Sapkota GP.   +4 more
europepmc   +1 more source

Disease mutations and phosphorylation alter the allosteric pathways involved in autoinhibition of protein phosphatase 2A. [PDF]

J Chem Phys, 2023
Konovalov KA, Wu CG, Qiu Y, Balakrishnan VK, Parihar PS, O'Connor MS, Xing Y, Huang X.   +7 more
europepmc   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Retraction: Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair. [PDF]

Oncotarget
Lv P, Wang Y, Ma J, Wang Z, Li JL, Hong CS, Zhuang Z, Zeng YX.   +7 more
europepmc   +1 more source