Results 231 to 240 of about 573,078 (335)

HSP105 Recruits Protein Phosphatase 2A To Dephosphorylate β-Catenin

Molecular and Cellular Biology, 2015
N. Yu, Michael Kakunda, Victoria C. Pham, J. Lill, Pan Du, M. Wongchenko, Yibing Yan, R. Firestein, Xiaodong Huang   +8 more
semanticscholar   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α. [PDF]

NPJ Metab Health Dis
Sergienko NM, Trewin AJ, Kiriazis H, Raaijmakers AJA, Donner DG, Garside VC, Smith KA, Bell JR, Mellor KM, Delbridge LMD, McMullen JR, Weeks KL.   +11 more
europepmc   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

A combination of protein phosphatase 2A inhibition and checkpoint immunotherapy: a perfect storm. [PDF]

Mol Oncol
Clark MC, Lu RO, Ho WS, Dias MH, Bernards R, Forman SJ.   +5 more
europepmc   +1 more source

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart

Science Signaling, 2015
Sean C. Little, J. Curran, Michael A. Makara, C. F. Kline, Hsiang‐Ting Ho, Zhaobin Xu, Xiangqiong Wu, I. Polina, H. Musa, Allison M. Meadows, C. Carnes, B. Biesiadecki, Jonathan P. Davis, N. Weisleder, S. Györke, X. Wehrens, T. Hund, P. Mohler   +17 more
semanticscholar   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

The cellular protein phosphatase 2A is a crucial host factor for Marburg virus transcription. [PDF]

J Virol
von Creytz I, Rohde C, Biedenkopf N.
europepmc   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Retraction: Neuroprotective effect of protein phosphatase 2A/tristetraprolin following subarachnoid hemorrhage in rats. [PDF]

Front Neurosci
Frontiers Editorial Office.
europepmc   +1 more source