Results 161 to 170 of about 625,556 (313)

Protein phosphatase 2Cδ/Wip1 regulates phospho-p90RSK2 activity in lesional psoriatic skin

, 2017
Mads K Rasmussen, Jakob Nielsen, Rasmus B Kjellerup, Stine M Andersen, Anne H Rittig, Claus Johansen, Lars Iversen, Borbala Gesser Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark Objectives: P90 ...
Rittig AH, Kjellerup RB, Andersen SM, Gesser B, Johansen C, Rasmussen MK, Nielsen J, Iversen L   +7 more
core  

Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus.

, 2014
This work was funded by a grant from a local trust administered by Tenovus (Tayside) (CP and AM), the Biotechnology and Biological Sciences Research Council grant award number D13460 (CP and JC), and funds from the Medical Research Council, UK (PTWC ...
Cohen, PT, Palmer, CN, Boyle, DI, Morris, AD, Cecil, Joanne Elizabeth, Doney, AS, Fischer, B, Leese, G   +7 more
core   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Inhibitory effects of rubratoxin A, a potent inhibitor of protein phosphatase 2, on the Ca²⁺-dependent contraction of skinned carotid artery from guinea pig. [PDF]

J Smooth Muscle Res, 2019
Naraki Y, Watanabe M, Takeya K.
europepmc   +1 more source

The role of AMPK and CREB-1 in the regulation of mitochondrial biogenesis during muscle differentiation

, 2007
The aim of the study was to identify main regulators of mitochondrial biogenesis in a skeletal muscle differentiation model. To investigate candidate factors we used the cytochrome c promoter as a representative promoter since cytochrome c levels ...
Frankó, András
core  

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro. [PDF]

J Biol Chem, 2018
Yeh ST, Zambrano CM, Koch WJ, Purcell NH.   +3 more
europepmc   +1 more source

Filament structure and phosphatase activity in the Rivulariaceae [PDF]

, 1989
A study was carried out on phosphatase activity, phosphate uptake and its relationship to hair formation in the Rivulariaceae. The Rivulariaceae was chosen as it is a widespread taxon, where hair formation is a common occurrence, and previous studies ...
Grainger, Stewart L.J.
core  

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Protein Phosphatase Slingshot Homolog 2 [PDF]

, 2020
openaire   +1 more source